120279-88-1

120279-88-1 - Names and Identifiers

Name	6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
Synonyms	5,6-DIHYDRO-6-METHYL-THIENO[2,3-B]THIOPYRAN-4-ONE-2-SULFONAMIDE 6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-yl sulfite 6-methyl-4-oxo-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide 6-Methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 6-methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]-thiopyran-2-sulfonamide 5,6-dihydro-6-methyl-4-oxo-4H-thieno-[2,3,b]thiopyran-2-sulfonamide 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 5,6-dihydro-6-methyl-4-oxo- (±)-6-methyl-4-oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide ()-6-METHYL-4-OXO-5D1,6-DIHYDRO-4H-THIENO[2,3-B]THIOPYRAN-2-SULFONAMIDE (±)-6-Methyl-4-oxo-5,6-dihydro-4H-Thieno[2,3-b]thiopyran-2-sulphonamide 5,6-Dihydro-6-methylthieno[2,3-b]thiopyran-4-one-2-sulfonamide(DorzolamideIntermediate)
CAS	120279-88-1
EINECS	601-694-3
InChI	InChI=1/C8H9NO3S3/c1-4-2-6(10)5-3-7(15(9,11)12)14-8(5)13-4/h3-4H,2H2,1H3,(H2,9,11,12)

120279-88-1 - Physico-chemical Properties

Molecular Formula	C8H9NO3S3
Molar Mass	263.36
Density	1.543
Boling Point	520.6±60.0 °C(Predicted)
Flash Point	268.677°C
Solubility	Ethyl Acetate (Sparingly), Methanol
Vapor Presure	0mmHg at 25°C
Appearance	Solid
Color	Tan
pKa	9.63±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.646

120279-88-1 - Introduction

6-Methyl-4-oxo-5, 6-dihydro-4H-thieno [2,3-b] thiopyran-2-sulfonamide is an organic compound. The following is a description of the nature, use, preparation and safety information of the substance:

Nature:
-Appearance: Colorless to light yellow crystalline solid.
-Molecular formula: C10H9NO3S2.
-Molecular weight: 259.31g/mol.
-Melting point: about 150-152 degrees Celsius.
-Solubility: Soluble in organic solvents such as ether and dichloromethane, insoluble in water.

Use:
-6-Methyl-4-oxo-5, 6-dihydro-4H-thieno [2,3-b] thiopyran -2-sulfonamide is commonly used in pharmaceutical research and synthesis.
-It can be used as an effective catalyst to participate in organic synthesis reactions, such as sulfonation, oxidation, etc.

Preparation Method:
The synthesis of 6-methyl-4-oxo-5, 6-dihydro-4H-thieno [2,3-b] thiopyran -2-sulfonamide can be carried out by the following steps:
1. Dissolve 4-oxygen -5, 6-dihydro-4H-thieno [2,3-b] thiopyran in thionyl chloride.
2. Add methanesulfonyl chloride and react at low temperature.
3. Further, sulfoxide and azodiphenol are added to perform a condensation reaction.
4. Finally, the product was obtained by distillation and crystallization.

Safety Information:
-6-Methyl-4-oxo-5, 6-dihydro-4H-thieno [2,3-b] thiopyran-2-sulfonamide may be irritating to the eyes, skin, and respiratory tract.
-Wear suitable protective gloves, glasses and protective clothing when handling or using the compound.
-Avoid inhaling dust or solution of the substance and avoid contact with skin.
-In case of accidental contact, flush the affected area immediately with plenty of water and seek medical help.

Please note that the handling and use of chemical substances should strictly follow the safety operating procedures and be carried out under professional guidance.

Last Update：2024-04-09 21:00:56