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1405-53-4

Tylosin Phosphate

CAS: 1405-53-4

Molecular Formula: C46H80NO21P

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1405-53-4 - Names and Identifiers

Name Tylosin Phosphate
Synonyms TYLAN
Farmazin TB
Pharmasine TB
Tylan 10 premix
Tylan 40 premix
ylosin phosphate
Einecs 215-779-4
Tylosin Phosphate
TYLOSIN PHOSPHATE
Tylosin, phosphate (salt)
2-[12-[5-(4,5-DIHYDROXY-4,6-DIMETHYL-OXAN-2-YL)OXY-4-DIMETHYLAMINO-3-HYDROXY-6-METHYL-OXAN-2-YL]OXY-2-ETHYL-14-HYDROXY-3-[(5-HYDROXY-3,4-DIMETHOXY-6-METHYL-OXAN-2-YL)OXYMETHYL]-5,9,13-TRIMETHYL-8,16-DIOXO-1-OXACYCLOHEXADECA-4,6-DIEN-11-YL]ACETALDEHYDE, PHOSPHORIC ACID
[(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-β-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-β-D-allopyranoside phosphate (salt)
2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde phosphate
-2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-Dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde phosphate
CAS 1405-53-4
EINECS 215-779-4
InChI InChI=1/C46H77NO17.H3O4P/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;1-5(2,3)4/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;(H3,1,2,3,4)/b15-14+,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;/m1./s1

1405-53-4 - Physico-chemical Properties

Molecular FormulaC46H80NO21P
Molar Mass1014.1
Melting Point>128°C (dec.)
Boling Point980.7°C at 760 mmHg
Flash Point546.9°C
Solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Vapor Presure0mmHg at 25°C
AppearanceWhite to white-like powder
ColorPale Yellow
Storage Condition2-8°C
StabilityHygroscopic
MDLMFCD06795692
In vitro study Tylosin phosphate exerts antibacterial effects by binding to 23S rRNA of the bacterial ribosomal 50S subunit . Tylosin phosphate also prevents growth of Gram-negative strains, with MICs of 64 μg/mL, 32 μg/mL, 512 μg/mL and 1 μg/mL for M. haemolytica 11935, P. multocida 4407, E. coli ATCC 25922 and E. coli AS19rlmA I , respectively.

1405-53-4 - Risk and Safety

WGK Germany2
RTECSYP0625000
ToxicityTylosin base and its salts were shown to be of low acute oral toxicity with LD50 values in excess 5000 mg/kg bw in the rat and mouse and greater than 800 mg/kg bw in the dog.

1405-53-4 - Reference Information

special antibiotic tylosin phosphate is the phosphate form of tylosin. tylosin is a macrolide and animal-specific antibiotic obtained from the culture medium of Actinomycete genus Streptomyces Streptomyces (fradiae) in the United States in 1959. Tylosin exists in the form of tylosine in the body. By combining with the ribosomes of pathogenic microorganisms and inhibiting the activity of bacterial transaminases, it hinders mRNA translocation, hinders the growth of peptide chains of sensitive microorganisms, and affects the synthesis of bacterial proteins. It has antibacterial and bactericidal effects.
product features 1. anti-mycoplasma effect: it has a strong inhibitory effect on pleuropneumonia and mycoplasma, and is the first choice for mycoplasma infectious diseases in livestock and poultry. 2. Broad antibacterial spectrum: It mainly has a strong inhibitory effect on a variety of Gram-positive bacteria, and has an inhibitory effect on some Gram-negative bacteria, Curvulus, and spirochetes, and has an anti-coccidia effect. 3. Rapid absorption and excretion: oral or injection can reach the effective inhibitory concentration in a short time (10 minutes) and maintain it for a certain period of time. After stopping the drug, it is quickly excreted from the body, and there is almost no residue in the tissue. 4. Good diffusion ability: It can penetrate into all organs, tissues and body fluids, especially through the plasma membrane, blood brain, blood eye and blood testis barrier, making the clinical application of Tylosin a wide range. 5. Specificity of use: Tylosin is a special antibiotic for livestock and poultry, which avoids the cross-drug resistance problem that is prone to occur when humans and animals share antibiotics.
biological activity Tylosin phosphate is a macrolide antibiotic (antibiotic), which is the product of Streptomyces fradiae. Tylosin phosphate has high antibacterial activity against gram-positive bacteria. Tylosin phosphate is a kind of feed additive widely used to promote animal growth. Tylosin phosphate are used to treat bacillary dysentery and respiratory diseases in poultry, pigs and cattle.
target Antibiotic
Animal Model: Balb/C mice (2-3 months old, 20-25 g)
Dosage: 10 mg/kg, 100 mg/kg, 500 mg/kg
Administration: Subcutaneous injection
Result: Reduced the elevated TNF-α and IL-1β in LPS (250 µg)-treated mice but increased their IL-10 levels.
Last Update：2024-04-09 15:16:47
1405-53-4
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Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Tylosin Phosphate Request for quotation
CAS: 1405-53-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Tylosin phosphate Visit Supplier Webpage Request for quotation
CAS: 1405-53-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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1405-53-4
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