14984-68-0
cloperastine hydrochloride
CAS: 14984-68-0
Molecular Formula: C20H25Cl2NO
14984-68-0 - Names and Identifiers
14984-68-0 - Physico-chemical Properties
| Molecular Formula | C20H25Cl2NO |
| Molar Mass | 366.32 |
| Melting Point | 147.9° |
| Boling Point | 423.9°C at 760 mmHg |
| Flash Point | 210.2°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 2.15E-07mmHg at 25°C |
| Appearance | neat |
| Color | White to Off-White |
| Merck | 14,2395 |
| Storage Condition | Inert atmosphere,Room Temperature |
| In vitro study | Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with an IC 50 value of 27 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects. |
| In vivo study | In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD 50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively. |
14984-68-0 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | TM6491500 |
14984-68-0 - Reference
| Reference Show more | 1. [IF=3.591] Meng Li et al."Chiral separation of five antihistamine drug enantiomers and enantioselective pharmacokinetic study of carbinoxamine in rat plasma by HPLC-MS/MS."New J Chem. 2020 Apr;44(15):5819-5827 |
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