Cloperastine MedChemExpress (MCE)

Product Name	cloperastine hydrochloride
Synonyms	Seki ht11 hustazol UNII-PI4N7C63ND Cloperastine HCl cloperastinacloridrato Cloperastina cloridrato Synonyms Seki ht11 hustazol UNII-PI4N7C63ND Cloperastine HCl cloperastinacloridrato Cloperastina cloridrato cloperastine hydrochloride CHLOPERASTINE HYDROCHLORIDE Cloperastina cloridrato [Italian] 2-piperidinoethylp-chlorobenzhydryletherhydrochloride 2-Piperidinoethyl p-chlorobenzhydryl ether hydrochloride 4-CHLOROBENZHYDRYL 2-[1-PIPERIDYL]-ETHYL ETHER HYDROCHLORIDE 1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato 1-(2-(p-Cloro-alpha-fenilbenzilossi)etil)piperidina cloridrato 1-(2-((4-Chlorophenyl)phenylmethoxy)ethyl)piperidinium chloride 1-(2-((4-Chlorophenyl)(Phenyl)Methoxy)Ethyl)Piperidine Hydrochloride 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride 1-(2-((p-Chloro-alpha-phenylbenzyl)oxy)ethyl)piperidine hydrochloride 1-(2-(p-Cloro-alpha-fenilbenzilossi)etil)piperidina cloridrato [Italian] Piperidine, 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-, hydrochloride Piperidine, 1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)-, hydrochloride (9CI)
CAS	14984-68-0
EINECS	239-067-8
Chemical Formula	C20H25Cl2NO
Molecular Weight	366.32
inchi	InChI=1/C20H24ClNO.ClH/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;/h1,3-4,7-12,20H,2,5-6,13-16H2;1H
Package	10 mM * 1 mL;500 mg
Price	Email to quote
Descriptions	Cloperastine hydrochloride Cloperastine hydrochloride MedChemExpress (MCE) HY-B2133 14984-68-0 99.39% 4°C, stored under nitrogen In solvent : -80°C, 6 months Descriptions Cloperastine hydrochloride Cloperastine hydrochloride MedChemExpress (MCE) HY-B2133 14984-68-0 99.39% 4°C, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen) Room temperature in continental US may vary elsewhere. Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM. Cloperastine inhibits the hERG K+ currents in a concentrationdependent manner with an IC50 value of 27 nM[1].?Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects[2]. In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic?action potential (MAP) duration without affecting PR interval or QRS width[1]. ?Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively[2]. 27 nM (K+ currents)[1] In Vitro Cloperastine inhibits the hERG K+ currents in a concentrationdependent manner with an IC50 value of 27 nM[1].?Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Cloperastine hydrochloride Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Takahara A, et al. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. J Pharmacol Sci. 2012 120(3):165-75. [Content Brief] [2]. Catania MA, et al. Pharmacological and clinical overview of cloperastine in treatment of cough. Ther Clin Risk Manag. 2011 7:83-92. [Content Brief]
Last Update	2025-04-01 14:45:47

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