150399-23-8
Pemetrexed disodium
CAS: 150399-23-8
Molecular Formula: C20H22N5NaO6
150399-23-8 - Names and Identifiers
| Name | Pemetrexed disodium |
| Synonyms | PEMETREXED SODIUM Premetred disodium Pemetrexed Disodium PEMETREXED DISODIUM Pemetrexed disodium PEMETREXED DISODIUM 2.5H2O PEMETREXED DISODIUM(ALIMTA) PEMETREXED DISODIUM FOR INJECTION PEMETREXED DISODIUM FOR INJECTION BK-A-01 N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-D-glutamic acid n-[4-[2-(2-amino-4,7-dihydro-4-oxo-1h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid disodium salt 2-[4-[2-(4-Amino-2-oxo-3,5,7-triazabicyclo[4.3.0]nona-3,8,10-trien-9-yl)ethyl]benzoyl]aminopentanedioic acid disodium salt |
| CAS | 150399-23-8 |
| EINECS | 604-733-2 |
| InChI | InChI=1/C20H21N5O6.2Na.7H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;7*1H2/q;2*+1;;;;;;;/p-2 |
150399-23-8 - Physico-chemical Properties
| Molecular Formula | C20H22N5NaO6 |
| Molar Mass | 451.41 |
| Melting Point | 254-258°C (dec.) |
| Boling Point | 160℃ 20mm |
| Solubility | DMSO <1 mg/mL Water 94 mg/mL Ethanol <1 mg/mL |
| Appearance | Crystalline solid |
| Color | Off-White |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Stability | Hygroscopic |
| In vitro study | Pemetrexed effectively inhibits thymidylate synthase (TS) with K I of 1.3 nM and also significantly inhibits other key folate enzymes, including dihydrofolate reductase (DHFR) and glycinamide nucleotide carbamoyltransferase (GARFT) , K I was 7.2 nM and 65 nM, respectively. Pemetrexed has antiproliferative activity in CCRF-CEM leukemia, GC3/C1 colon cancer, and HCT-8 ileocecal cancer cells with IC50 of 25 nM, 34 nM, and 220 nM, respectively. Moreover, the combination of thymidine and hypoxanthine on the above three cell lines can completely reverse the cytotoxicity caused by ly231514. Recent studies have shown that the combination of Cisplatin and Pemetrexed has anti-cancer effects by inhibiting cell proliferation, invasion, and inducing apoptosis in MPM cells infected with Adenovirus of the vectors expressing SOCS-1. |
| In vivo study | Pemetrexed acts on human H460 non-small cell lung cancer xenograft, delaying tumor growth. Furthermore, Pemetrexed in combination with paclitaxel delayed H460 tumor growth to a greater extent and in addition to Vinorelbine and Carboplatin. |
150399-23-8 - Risk and Safety
| Risk Codes | R36/38 - Irritating to eyes and skin. R60 - May impair fertility R61 - May cause harm to the unborn child R68 - Possible risk of irreversible effects |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S53 - Avoid exposure - obtain special instructions before use. |
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