152044-54-7
Epothilone B
CAS: 152044-54-7
Molecular Formula: C27H41NO6S
152044-54-7 - Names and Identifiers
152044-54-7 - Physico-chemical Properties
| Molecular Formula | C27H41NO6S |
| Molar Mass | 507.68 |
| Density | 1.136 |
| Melting Point | 95-97°C |
| Boling Point | 680.2±55.0 °C(Predicted) |
| Specific Rotation(α) | D21 -35° (c = 0.7 in methanol) |
| Flash Point | 365.165°C |
| Solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 35 mg/ml). |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| Color | colorless |
| pKa | 13.57±0.70(Predicted) |
| Storage Condition | Store at -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Sensitive | Sensitive to light |
| Refractive Index | 1.532 |
| MDL | MFCD02101921 |
| Use | (-)-Epomycin B is a stable drug of microtubules (MT), derived from natural myxobacteria Sorangium cellulosum, and is a macrolide anti-tumor factor. The biological characteristics of EpoB and EpoA are similar. However, EpoB is 10 times more effective than EpoA in multidrug-resistant (MDR) cells (IC50=2 nM for MDR CCRF-CEM/VBL100 cells) that express P-glycoprotein. (-)-epothol B is similar to paclitaxel and is an alternative to paclitaxel in cell growth. EpoB leads to cell cycle arrest (IC50=3.5 nM).. |
| In vitro study | Epothilone B is more active than Epothilone A. Epothilone B has an EC0.01 of 1.8 nM. Epothilone B acted on HCT116 cells and effectively inhibited cell proliferation with an IC50 of 0.8 nM. Epothilone B induces cell cycle arrest in KB3-1, KBV-1, Hela, and Hs578T cells and is cytotoxic with an IC50 of 3 nM to 92 nM. Epothilone B competes with paclitaxel for binding to microtubules with an IC50 of 3.3 μm. 3.5 nM Epothilone B acts on MCF-7 cells overexpressing GFP-α-tubulin, sufficiently inhibiting microtubule dynamics. At the same time, Epothilone B induced mitotic arrest with an IC50 of 3.5 nM. Epothilone B acts on multiple myeloma (MM) cells, including RPMI 8226, U266, MM.1s, LR5, and MR20, and directly inhibits cell proliferation with an IC50 of 1 nM to 10 nM. 10 nM Epothilone B also induced cell cycle arrest and apoptosis. Recent studies have shown that 5 nM-100 nM Epothilone B acts on ovarian cancer Hey cells to enhance surface epithelial cell adhesion antigen (EpCAM). |
| In vivo study | Epothilone B at a dose of 2.5 mg/kg-4 mg/kg in mice bearing RPMI 8226 cell xenografts prolongs the life of mice and inhibits tumor growth. Epothilone B also inhibited tumor growth in mice bearing xenografts of prostate cancer cells, including DU145 and PC3. |
152044-54-7 - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29419090 |
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Spot supply
Product Name: Epothilone B Visit Supplier Webpage Request for quotationCAS: 152044-54-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Epothilone B Visit Supplier Webpage Request for quotation
CAS: 152044-54-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 152044-54-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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