15790-02-0
Tropodifene
CAS: 15790-02-0
Molecular Formula: C25H29NO4
15790-02-0 - Names and Identifiers
| Name | Tropodifene |
| Synonyms | Tropaphen Tropodifene Benzenepropanoic acid, 4-(acetyloxy)-α-phenyl-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester |
| CAS | 15790-02-0 |
15790-02-0 - Physico-chemical Properties
| Molecular Formula | C25H29NO4 |
| Molar Mass | 407.507 |
| Density | 1.20±0.1 g/cm3(Predicted) |
| Boling Point | 508.5±50.0 °C(Predicted) |
| pKa | 9.99±0.40(Predicted) |
| Storage Condition | Room Temprature |
| In vivo study | Tropaphen has a beneficial effect on hypertension. The therapeutic effect of this preparation is more constant in diseases accompanied by spasm of the peripheral vessels. Tropaphen has a very marked adrenolytic and vasodilator action. It greatly lowers the tone of the peripheral vessels. The preparation is effective starting with a dose of 0.1 mg/kg. After injection of the drug in a dose of 0.25 mg/kg, a considerable and gradually progressive decrease in the perfusion pressure takes place. The pressure falls by 30-35% and remained at a low level for 90-100 min. With a dose of tropaphen of 0.5 mg/kg, the perfusion pressure falls by 40-45% and remains low for 120 min or more. Strong vasodilatation is also observed after injection of tropaphen into intact rabbits. |
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