Name | Tropodifene |
Synonyms | Tropaphen Tropodifene Benzenepropanoic acid, 4-(acetyloxy)-α-phenyl-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester |
CAS | 15790-02-0 |
Molecular Formula | C25H29NO4 |
Molar Mass | 407.507 |
Density | 1.20±0.1 g/cm3(Predicted) |
Boling Point | 508.5±50.0 °C(Predicted) |
pKa | 9.99±0.40(Predicted) |
Storage Condition | Room Temprature |
In vivo study | Tropaphen has a beneficial effect on hypertension. The therapeutic effect of this preparation is more constant in diseases accompanied by spasm of the peripheral vessels. Tropaphen has a very marked adrenolytic and vasodilator action. It greatly lowers the tone of the peripheral vessels. The preparation is effective starting with a dose of 0.1 mg/kg. After injection of the drug in a dose of 0.25 mg/kg, a considerable and gradually progressive decrease in the perfusion pressure takes place. The pressure falls by 30-35% and remained at a low level for 90-100 min. With a dose of tropaphen of 0.5 mg/kg, the perfusion pressure falls by 40-45% and remains low for 120 min or more. Strong vasodilatation is also observed after injection of tropaphen into intact rabbits. |