Preparation | Using 4-methoxy-2-methylpyridine as raw material, it is oxidized by m-chloroperoxybenzoic acid (m-CPBA) to obtain 4-methoxy-2-methylpyridine-1-oxide, 4-methoxy-2-methylpyridine-1-oxide reacts with trifluoroacetic anhydride to hydrolyze to obtain 4-methoxy-2-hydroxymethylpyridine trifluoroacetate salt, the target compound (4-methoxypyridine-2-yl) methanol [1] is then free. (4-methoxypyridine-2-yl) methanol synthesis reaction formula is as follows: fig. 1 (4-methoxypyridine-2-yl) methanol synthesis reaction formula |