171335-80-1
Exatecan
CAS: 171335-80-1
Molecular Formula: C24H22FN3O4
171335-80-1 - Names and Identifiers
171335-80-1 - Physico-chemical Properties
| Molecular Formula | C24H22FN3O4 |
| Molar Mass | 435.45 |
| Density | 1.53±0.1 g/cm3(Predicted) |
| Boling Point | 818.4±65.0 °C(Predicted) |
| pKa | 11.19±0.40(Predicted) |
| In vitro study | Exatecan is a potent topoisomerase I inhibitor, with an IC 50 of 0.975 μg/mL. Exatecan Mesylate (DX-8951f) significantly inhibits the proliferation of several cancer cell lines, with mean GI 50 s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively. Exatecan Mesylate (DX-8951f) displays cytotoxic activities against PC-6, PC-6/SN2-5 cells, with mean GI 50 s of 0.186 and 0.395 ng/mL, respctively. Exatecan Mesylate (34 nM) stabilizes DNA-TopoI complexes in PC-6 and PC-6/SN2-5 cells. |
| In vivo study | Exatecan Mesylate (DX-8951f, 3.325-50 mg/kg, i.v.) exhibits antitumor activities in the mice model bearing tumor cells, without toxic death. Exatecan Mesylate (15, 25 mg/kg, i.v.) hightly inhibits MIA-PaCa, BxPC-3 primary tumor growth in the MIA-PaCa-2 early-stage model and early-stage model of BxPC-3. Exatecan Mesylate (15, 25 mg/kg, i.v.) also significantly suppresses BxPC-3 lymphatic metastasis and completely eliminates lung metastasis in the BxPC-3 late-stage cancer model. |
171335-80-1 - References
| biological activity | icotecan (DX-8951) is a DNA topoisomerase I inhibitor, the IC50 value is 2.2 μm (0.975 μg/mL) and can be used for cancer research. |
Last Update：2024-04-09 19:05:20
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Spot supply
Product Name: Exatecan Visit Supplier Webpage Request for quotationCAS: 171335-80-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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