Name | Cholesteryl myristate |
Synonyms | CM Cholestryl myristate Cholesteryl myristate Cholesterol myristate Cholesteryl Tetradecanoate Cholest-5-en-3-yl myristate MYRISTIC ACID CHOLESTEROL ESTER cholest-5-en-3-yl tetradecanoate 3β-tetradecanoyloxycholest-5-ene (3β)-cholest-5-en-3-yltetradecanoate (3beta)-cholest-5-en-3-yl myristate (3beta)-cholest-5-en-3-yl tetradecanoate Cholest-5-en-3-ol (3beta)-, tetradecanoate |
CAS | 1989-52-2 |
EINECS | 217-867-8 |
InChI | InChI=1/C41H72O2/c1-7-8-9-10-11-12-13-14-15-16-17-21-39(42)43-34-26-28-40(5)33(30-34)22-23-35-37-25-24-36(32(4)20-18-19-31(2)3)41(37,6)29-27-38(35)40/h22,31-32,34-38H,7-21,23-30H2,1-6H3 |
Molecular Formula | C41H72O2 |
Molar Mass | 597.01 |
Density | 0.9309 (rough estimate) |
Melting Point | 84 °C |
Boling Point | 589.77°C (rough estimate) |
Flash Point | 334.8°C |
Solubility | Chloroform (Slightly), Hexanes (Slightly) |
Vapor Presure | 8.15E-16mmHg at 25°C |
Appearance | White powder |
Storage Condition | Sealed in dry,2-8°C |
Refractive Index | 1.5250 (estimate) |
Use | This product is for scientific research only and shall not be used for other purposes. |
In vitro study | Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
Reference Show more | 1. Song, Z., Lu, Y., Zhang, X., Wang, H., Han, J., & Dong, C. (2016). Novel curcumin-loaded human serum albumin nanoparticles surface functionalized with folate: characterization and in vitro/vivo evaluation. Drug design, development and therapy, 10, 2643–264 |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
biological activity | Cholesterol myristate are natural steroids in traditional Chinese medicine. Cholesterol myristate are bound to a variety of ion channels, such as nAChR,GABAA receptor and inward rectifying potassium ion channels (potassium ion channel). |