2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Names and Identifiers

Name	2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone
Synonyms	D-vc isona ozoban erbitn eribaten mercate20 isoascorbic neo-cebitate acid sodium salt sodium erythorbate sodium-iso-ascorbate sodiumerythorbicacid isoascorbic acid(rg) sodium d-isoascorbate d-sodium isoascorbiate sodium d-araboascorbate sodium erythorbate fcciv sodiumenolatemonohydrate sodiumerythorbate,fcc(bulk d-isoascorbic acid na salt 3-keto-d-gulofuranolactose erythorbic acid sodium salt araboascorbinicacidsodiumsalt d-isoascorbic acid sodium salt erythorbic acid monosodium salt d-araboascorbic acid sodium salt d(+)-isoascorbic acid sodium salt D-erythro-hex-1-enofuranos-3-ulose sodiumd-erythro-3-oxohexonatelactone 2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone 2,3-Didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone 2,3-didehydro-3-o-natrio-d-erythro-hexono-1,4-lacton d-erythro-hex-2-enonic acid gamma-lactone monosodium salt sodium 2-(4,5-dihydroxy-3-oxo-2,3-dihydrofuran-2-yl)-2-hydroxyethanolate (non-preferred name) sodium (2R)-2-[(2R)-4,5-dihydroxy-3-oxo-2,3-dihydrofuran-2-yl]-2-hydroxyethanolate (non-preferred name)
CAS	6381-77-7 7378-23-6
EINECS	228-973-9
InChI	InChI=1/C6H7O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,8-10H,1H2;/q-1;+1/t2-,5-;/m1./s1

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Physico-chemical Properties

Molecular Formula	C6H7NaO6
Molar Mass	198.11
Density	1.702[at 20℃]
Melting Point	154-164°C (decomposes)
Specific Rotation(α)	97 º (c=1,DMF)
Water Solubility	146g/L at 20℃
Solubility	Soluble in water
Vapor Presure	0Pa at 25℃
Appearance	White or slightly yellow crystalline particles or powder
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	97 ° (C=10, H2O)
MDL	MFCD00067298
Physical and Chemical Properties	White to yellowish white crystalline powder or granules. Almost odorless. Slightly salty. The dry state is quite stable in air. But in solution, in the presence of air, trace metals, heat and light in the presence of deterioration. The melting point is above 200 ° C (decomposition). Soluble in water (17g/100 m1). Slightly insoluble in ethanol. The pH of the 2% aqueous solution is 5.5-8.0.
Use	Used as food antioxidants, preservative color aids

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Risk and Safety

RTECS

MP8910000

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Upstream Downstream Industry

Raw Materials	Starch potato Methyl alcohol Sodium hydroxide
Downstream Products	L(+)-Ascorbic acid

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Reference

Reference

1. Li Yuncheng, du Wen, Meng Fanbing et al. Study on industrial processing technology of ready-to-eat spicy rabbit meat [J]. Chinese condiment 2020 v.45;No.496(06):110-113.
2. Qingyuan. Study on the technology of truffle sauce [J]. Chinese condiment, 2016,41(12):77-80.

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Nature

Open Data Verified Data

white or slightly yellowish crystalline powder or granules, odorless and slightly salty. Easily soluble in water. The pH value of the 2% aqueous solution is 6.5-8.0. Dry state in the air stability, light, heat and copper, iron and other metal ions easily oxidized.

Last Update：2024-01-02 23:10:35

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Preparation Method

Open Data Verified Data

with glucose as raw material, after fermentation and then by esterification, the refined.

Last Update：2022-01-01 10:08:49

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Introduction

Odorless, slightly salty, dry state in the air stable, when the aqueous solution meets the air, trace metal, heat and light easy to deteriorate.

Last Update：2022-10-16 17:27:37

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Use

Open Data Verified Data

sodium erythorbate is a water-soluble antioxidant, which is an important antioxidant in the food industry. Its antioxidant performance is better than that of vitamin C, and the price is cheap, and without any side effects. In the food industry, it is mainly used for meat products, fruits, vegetables, cans, jam, beer, soda, fruit tea, fruit juice, wine and so on. China provides for all kinds of canned, jam and frozen fish, the maximum use of 1.Og/kg; Can also be used for meat products, the maximum use of 0. 5g/kg (ascorbic acid); Can also be used for wine and fruit juice drinks, the maximum use of 0. 15g/kg; Can also be used for beer, the maximum use of 0. 04g/kg.

Last Update：2022-01-01 10:08:50

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Reference Information

LogP	-3.29
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Introduction	sodium erythorbate is white to yellow-white crystal granules or crystal powder, odorless, slightly salty, the melting point of 200 degrees above the decomposition, in the dry state exposure to air is quite stable. But in aqueous solution, when there is air, metal, heat, light, oxidation occurs, it is soluble in water 55g/100ml, almost insoluble in ethanol, the pH of the 2% aqueous solution is 6.5-8.0. The antioxidant capacity of sodium erythorbate far exceeds that of sodium vitamin C, without strengthening the role of vitamin C, but will not hinder the absorption and use of ascorbic acid by the human body. The human body take a pinch of sodium erythorbate, in the body can be converted into vitamin C.
physiological functions and effects	physiological effects of sodium erythorbate, the role in the fight against bad blood is only about 1/20 of that of ascorbic acid, but the role in lowering blood pressure, diuresis, liver glycogen production, pigment excretion, detoxification, etc., is roughly the same as that of ascorbic acid.
application field	sodium erythorbate is mainly used in food industry, as an antioxidant in food, widely used in meat food, fish food, beer, fruit juices, juice crystals, canned fruits and vegetables, cakes, dairy products, jam, wine, pickle, fat, etc. The dosage of meat products is 0.5~1.0/kg. For frozen fish, they were impregnated with a 0.1%-0.8% aqueous solution prior to freezing. The amount used for a beverage such as fruit juice is 0.01% to 0.03%. Canned apple sauce, 0.15g/Kg (used alone or in combination with ascorbic acid) lunch meat, cooked meat, cooked pig fore leg meat, cooked ham, 0.5g/kg (single use with ascorbic acid and its sodium salt, ascorbic acid), peach, apple sauce: 2 g/kg canned fruit 0.75-1.5g/l, natural juice 0.08-0.11g/l. Beer 0.03g/l. (FAO/WHO(1977)).
preparation method	sodium erythorbate is fermented from D-glucose by Arthrobacter globosa or Pseudomonas fluorescens to calcium 2-keto-d-gluconate, after acidification with sulfuric acid and oxalic acid, calcium oxalate and calcium sulfate are removed by pressure filtration, concentrated, and esterified with methanol and a small amount of sulfuric acid to obtain solid methyl ester body, and then Methanol is used as solvent, after conversion with alkaline methanol, it is isolated and purified.
side effects	if it is sensitive to sodium erythorbate, it may cause side effects such as Head Pain, dizziness, fatigue, drowsiness and flushing of the body. However, hospitalizations for these adverse effects have not been reported.
identification test	solubility soluble in water; Extremely insoluble in ethanol, according to OT-42 method. 2ml of the first sample solution was taken, and 2ml of water, 2.0% g of sodium bicarbonate and about 0.02g of ferrous sulfate were added. After shaking, stand still. Should be dark purple, and when added to dilute sulfuric acid solution (TS-241) after 5ml, color disappeared. The combustion residue of the sample is dissolved in water, acidified with dilute acetic acid test solution (TS-2), filtered if necessary, and added with uranyl-zinc acetate test solution (TS-253) to produce yellow crystalline precipitate. The aqueous solution of the sample can make 2,6 one or two chlorine indophenol solution (TS-84) fading.
content analysis	take a sample 0.400g, pre-dried in a vacuum dryer (sulfuric acid) for 24h, dissolve in a mixture of TS-241 ml of decarbonized water and 25ml of dilute sulfuric acid solution (). Add a few drops of starch test solution (TS-235), and immediately titrate with 0.1mol/L iodine solution. Each mL0.1mol/L iodine equivalent to sodium erythorbate (C6H7O6Na? H2O)10.807mg.
toxicity	ADI is not specified (FAO/WHO,2001). LD50}15.3g/kg (mice, oral).
usage limit	GB 2760-2001(g/kg): beer 0.04; Wine, fruit and vegetable juices, 0.15; Meat products 0.50; canned fruits and vegetables, canned meat, jam, frozen fish, 1.0 (all ascorbic acid). FAO/WHO(1984): lunch meat, cooked pig front leg meat, cooked ham, cooked meat, 500mg/kg (single or with isoascorbic acid, ascorbic acid and its salts, calculated as ascorbic acid).
storage	sodium erythorbate is stored in a light-protected, dry, ventilated and cool warehouse.
Use	Antioxidant; Preservative. sodium erythorbate is a water-soluble antioxidant allowed to be used in China and widely used abroad. Its antioxidant properties greatly exceed vitamin C, and the price is cheap. China's provisions can be used for all kinds of canned, jam and frozen fish, the maximum use of 1.0g/kg; Can also be used for meat products, the maximum use of 0.5g/kg (ascorbic acid); can also be used for wine and fruit juice drinks, the maximum use of 0.15g/kg; Can also be used for beer, the maximum use of 0.04g/kg. it can be used as antioxidant and preservative aid in food Antioxidant in cosmetics. In cosmetics, oxygen can be consumed, high-valent metal ions can be reduced, the redox potential can be transferred to the reduction range, and the generation of undesirable oxidation products can be reduced. It can also be used as a preservative aid.
production method	production of 2-keto-d-gluconic acid (or calcium salt) by D-glucose fermentation with Pseudomonas fluorescens Kl005 or Arthrobacter globulus K1022, after esterification, conversion and purification. Fermentation medium composition (%): glucose 18, yeast extract 0.3,K2HPO4 · 3H2O 0.05,KH2PO40.05,MgSO4 · 7H2O0.025,CaC034.5; Fermentation temperature controlled at 30-35 ℃, fermentation period 30H, the fermentation conversion rate was 79.9%. Fermentation broth with sulfuric acid, activated carbon to acidification and decolorization, and then Plate and Frame pressure filtration to obtain a clear liquid, the yield of 96.6%; Purified fermentation broth was concentrated under reduced pressure, plus methanol, sulfuric acid reflux esterification 5H, frozen crystallization, the methyl ester was obtained by centrifugal filtration, and the yield of esterification was 82.1%. Methyl ester with methanol, alkaline methanol solution under reflux conditions for conversion, freeze crystallization, drying to D-isoascorbic acid sodium crude product, conversion yield of 87.3%; Dissolved in hot water and activated carbon decolorization, and heat preservation and pressure filtration, the clear liquid by freezing crystallization, centrifugal filtration, washing, vacuum drying to obtain the finished product, the mother liquor recovery, refined yield of 88.0%. From D-glucose by the spherical Arthrobacter or Pseudomonas fluorescens fermentation into 2-keto-d-glucan calcium, with sulfuric acid, oxalic acid after acidification, calcium oxalate and calcium sulfate are removed by pressure filtration, concentrated, and esterified with methanol and a small amount of sulfuric acid to obtain a solid methyl ester body, which is converted with methanol as a solvent and then separated and refined after being converted with alkaline methanol.
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-09 15:16:52

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone

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2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone

CAS: 6381-77-7;7378-23-6

Molecular Formula: C6H7NaO6

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Names and Identifiers

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Physico-chemical Properties

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Risk and Safety

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Upstream Downstream Industry

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Reference

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Nature

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2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Preparation Method

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2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Introduction

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Use

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2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone

CAS: 6381-77-7;7378-23-6

Molecular Formula: C6H7NaO6

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Names and Identifiers

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Physico-chemical Properties

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Risk and Safety

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Upstream Downstream Industry

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Reference

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Nature

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2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Preparation Method

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2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Introduction

2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Use

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2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone - Reference Information

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2,3-didehydro-3-O-sodio-D-erythro-hexono-1,4-lactone