2,5-OXAZOLIDINEDIONE
2,5-OXAZOLIDINEDIONE
CAS: 2185-00-4
Molecular Formula: C3H3NO3
2,5-OXAZOLIDINEDIONE - Names and Identifiers
| Name | 2,5-OXAZOLIDINEDIONE |
| Synonyms | GLY-NCA L-Gly-NCA 2,5-OXAZOLIDINEDIONE oxazolidine-2,5-dione 1,3-oxazolidine-2,5-dione GLYCINE-N-CARBOXYANHYDRIDE N-Carboxyglycine anhydride |
| CAS | 2185-00-4 |
| EINECS | 218-570-6 |
2,5-OXAZOLIDINEDIONE - Physico-chemical Properties
| Molecular Formula | C3H3NO3 |
| Molar Mass | 101.061 |
| Density | 1.469±0.06 g/cm3(Predicted) |
| Melting Point | 120 °C (dec.) (lit.) |
| Storage Condition | -20℃ |
| Use | 2, 5-oxazolidinedione can be used as pharmaceutical synthesis intermediates. Glycine-N-endocarboxylic anhydride, valine-N-endocarboxylic anhydride (2, 5-oxazolidinedione), leucine-N-endocarboxylic anhydride or alanine-N-endocarboxylic anhydride, the amphiphilic Polyamino acids with hydrophilic segments and hydrophobic segments can form nano-sized physical gels in water, and can form gels at a certain temperature, the physical gel can therefore be used as a carrier material for drug delivery and controlled release. |
2,5-OXAZOLIDINEDIONE - Upstream Downstream Industry
2,5-OXAZOLIDINEDIONE - Security information
| WGK Germany | 3 |
Last Update：2024-04-10 22:29:15
2,5-OXAZOLIDINEDIONE - Preparation
2, 5-oxazolidinedione is prepared as follows: under the condition of heating and stirring at 50 ℃, 20g of valine is dissolved in a dry three-mouth bottle with tetrahydrofuran removed from water, 12g of triphosgene is added with nitrogen, 5g of triphosgene is added one hour later, 2g of triphosgene is added two hours later, and 2g of triphosgene is added until clear; after blowing the obtained reaction product with nitrogen for half an hour, it is sequentially settled with cold n-hexane, cold ethyl acetate is dissolved, cold sodium bicarbonate solution is washed once, and then cold water is washed three times, and the washed product is mixed with anhydrous magnesium sulfate and then dried in the refrigerator overnight; the dried product is filtered, the solvent in the solution is dried, and then recrystallized and dried, valine-N-endocarboxylic anhydride (2, 5-oxazolidinedione) was obtained.
Last Update：2024-04-10 22:29:15
2,5-OXAZOLIDINEDIONE - Nature
| melting point | 120°C (dec.) (lit.) |
| density | 1.469±0.06 g/cm3(Predicted) |
| storage conditions | -20°C |
| acidity coefficient (pKa) | 9.32±0.20(Predicted) |
Last Update：2024-04-09 20:52:54
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View History
2,5-OXAZOLIDINEDIONE
崖椒碱,8-甲氧基白鲜碱
1-(4-氨基苯基)环丁基氨基甲酸叔丁酯
四氢-2H-吡喃-2-酮
(E)-HYDRAZINECARBOHYDRAZONAMIDE HYDROCHLORIDE
3-甲磺酰胺基苯硼酸
2-吲哚酮-6-羧酸
专利蓝五号钠盐
POLY(PROPYLENE GLYCOL) BIS(2-AMINOPROPYL ETHER), AVERAGE MN CA. 4,000
N-[4-(2-Ethoxyethoxy)benzyl]-3-(2-phenoxyethoxy)aniline
崖椒碱,8-甲氧基白鲜碱
1-(4-氨基苯基)环丁基氨基甲酸叔丁酯
四氢-2H-吡喃-2-酮
(E)-HYDRAZINECARBOHYDRAZONAMIDE HYDROCHLORIDE
3-甲磺酰胺基苯硼酸
2-吲哚酮-6-羧酸
专利蓝五号钠盐
POLY(PROPYLENE GLYCOL) BIS(2-AMINOPROPYL ETHER), AVERAGE MN CA. 4,000
N-[4-(2-Ethoxyethoxy)benzyl]-3-(2-phenoxyethoxy)aniline
Raw Materials for 2,5-OXAZOLIDINEDIONE
Ethanethioic acid, amino- (9CI)
N-(Methoxycarbonyl)glycine
NULL
SODIUM GLYCINATE
Triphosgene
Chloroform
Glycine
N-(Methoxycarbonyl)glycine
NULL
SODIUM GLYCINATE
Triphosgene
Chloroform
Glycine
Downstream Products for 2,5-OXAZOLIDINEDIONE