L-Gly-NCA
2,5-OXAZOLIDINEDIONE
CAS: 2185-00-4
Molecular Formula: C3H3NO3
L-Gly-NCA - Names and Identifiers
| Name | 2,5-OXAZOLIDINEDIONE |
| Synonyms | GLY-NCA L-Gly-NCA 2,5-OXAZOLIDINEDIONE oxazolidine-2,5-dione 1,3-oxazolidine-2,5-dione GLYCINE-N-CARBOXYANHYDRIDE N-Carboxyglycine anhydride |
| CAS | 2185-00-4 |
| EINECS | 218-570-6 |
L-Gly-NCA - Physico-chemical Properties
| Molecular Formula | C3H3NO3 |
| Molar Mass | 101.061 |
| Density | 1.469±0.06 g/cm3(Predicted) |
| Melting Point | 120 °C (dec.) (lit.) |
| Storage Condition | -20℃ |
| Use | 2, 5-oxazolidinedione can be used as pharmaceutical synthesis intermediates. Glycine-N-endocarboxylic anhydride, valine-N-endocarboxylic anhydride (2, 5-oxazolidinedione), leucine-N-endocarboxylic anhydride or alanine-N-endocarboxylic anhydride, the amphiphilic Polyamino acids with hydrophilic segments and hydrophobic segments can form nano-sized physical gels in water, and can form gels at a certain temperature, the physical gel can therefore be used as a carrier material for drug delivery and controlled release. |
L-Gly-NCA - Upstream Downstream Industry
L-Gly-NCA - Security information
| WGK Germany | 3 |
Last Update：2024-04-10 22:29:15
L-Gly-NCA - Preparation
2, 5-oxazolidinedione is prepared as follows: under the condition of heating and stirring at 50 ℃, 20g of valine is dissolved in a dry three-mouth bottle with tetrahydrofuran removed from water, 12g of triphosgene is added with nitrogen, 5g of triphosgene is added one hour later, 2g of triphosgene is added two hours later, and 2g of triphosgene is added until clear; after blowing the obtained reaction product with nitrogen for half an hour, it is sequentially settled with cold n-hexane, cold ethyl acetate is dissolved, cold sodium bicarbonate solution is washed once, and then cold water is washed three times, and the washed product is mixed with anhydrous magnesium sulfate and then dried in the refrigerator overnight; the dried product is filtered, the solvent in the solution is dried, and then recrystallized and dried, valine-N-endocarboxylic anhydride (2, 5-oxazolidinedione) was obtained.
Last Update：2024-04-10 22:29:15
L-Gly-NCA - Nature
| melting point | 120°C (dec.) (lit.) |
| density | 1.469±0.06 g/cm3(Predicted) |
| storage conditions | -20°C |
| acidity coefficient (pKa) | 9.32±0.20(Predicted) |
Last Update：2024-04-09 20:52:54
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View History
Raw Materials for L-Gly-NCA
Ethanethioic acid, amino- (9CI)
Glycine hydrochloride
N-Carbobenzyloxyglycine
Sodium bicarbonate
Chloroform
Glycine
PHOSGENE
Glycine hydrochloride
N-Carbobenzyloxyglycine
Sodium bicarbonate
Chloroform
Glycine
PHOSGENE
Downstream Products for L-Gly-NCA