2-(1H-Imidazol-2-yl)ethylamine
isohistamine
CAS: 19225-96-8
Molecular Formula: C5H9N3
2-(1H-Imidazol-2-yl)ethylamine - Names and Identifiers
| Name | isohistamine |
| Synonyms | isohistamine 1H-Imidazole-2-ethanamine 4-(β-aMinoethyl)iMidazole 2-(1H-Imidazol-2-yl)ethylamine 2-(1H-imidazol-2-yl)ethanamine 1H-IMidazole-2-ethanaMine (2HCl salt) 1H-Imidazole-2-ethanamine dihydrochloride 2-(1H-iMidazol-2-yl)ethanaMine (2HCl salt) |
| CAS | 19225-96-8 |
| InChI | InChI=1/C5H9N3/c6-2-1-5-7-3-4-8-5/h3-4H,1-2,6H2,(H,7,8) |
2-(1H-Imidazol-2-yl)ethylamine - Physico-chemical Properties
| Molecular Formula | C5H9N3 |
| Molar Mass | 111.15 |
| Density | 1.140±0.06 g/cm3(Predicted) |
| Boling Point | 341.9±25.0 °C(Predicted) |
| Flash Point | 187.3°C |
| Vapor Presure | 7.81E-05mmHg at 25°C |
| pKa | pK1:6.036(－2);pK2:9.274(＋1) (25°C,μ=0.1) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.567 |
2-(1H-Imidazol-2-yl)ethylamine - Risk and Safety
| Hazard Class | IRRITANT |
2-(1H-Imidazol-2-yl)ethylamine - Introduction
isohistamine, also known as 2-ethylaminoimidazole hydrochloride, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: isohistamine is a white crystalline solid.
-Solubility: It is easily soluble in water, but poorly soluble in organic solvents.
-Melting point: isohistamine has a high melting point.
Use:
-Chemical reagent: isohistamine is commonly used as an organic synthesis intermediate for the synthesis of other organic compounds.
-Catalyst: It can also be used as a catalyst for certain chemical reactions, such as catalyzing the synthesis of polypeptides using N-allyl isopropyl ketone amine or aminoethyl ester.
Method:
The preparation of isohistamine is usually carried out by the following steps:
1. Acetylacetonamide reacts with ammonia solution to generate acetylacetonamide amino Ammonium iodide salt.
2. Reacting acetylacetonamide aminoammonium iodide salt with ethylamine to generate 2-ethylaminoimidazole.
3.2-Ethyl amino imidazole is reacted with hydrochloric acid to generate the BIS-hydrochloride of 2-ethyl amino imidazole.
Safety Information:
Pay attention to the following safety information when using isohistamine:
-It should be operated in a well-ventilated laboratory environment.
-Avoid inhalation or skin contact, as it may cause irritation to the human body.
-Avoid contact with strong oxidants during use, as it may cause a fire or explosion.
-Personal protective equipment such as protective gloves, goggles and protective clothing must be worn during handling to ensure safe operation.
Nature:
-Appearance: isohistamine is a white crystalline solid.
-Solubility: It is easily soluble in water, but poorly soluble in organic solvents.
-Melting point: isohistamine has a high melting point.
Use:
-Chemical reagent: isohistamine is commonly used as an organic synthesis intermediate for the synthesis of other organic compounds.
-Catalyst: It can also be used as a catalyst for certain chemical reactions, such as catalyzing the synthesis of polypeptides using N-allyl isopropyl ketone amine or aminoethyl ester.
Method:
The preparation of isohistamine is usually carried out by the following steps:
1. Acetylacetonamide reacts with ammonia solution to generate acetylacetonamide amino Ammonium iodide salt.
2. Reacting acetylacetonamide aminoammonium iodide salt with ethylamine to generate 2-ethylaminoimidazole.
3.2-Ethyl amino imidazole is reacted with hydrochloric acid to generate the BIS-hydrochloride of 2-ethyl amino imidazole.
Safety Information:
Pay attention to the following safety information when using isohistamine:
-It should be operated in a well-ventilated laboratory environment.
-Avoid inhalation or skin contact, as it may cause irritation to the human body.
-Avoid contact with strong oxidants during use, as it may cause a fire or explosion.
-Personal protective equipment such as protective gloves, goggles and protective clothing must be worn during handling to ensure safe operation.
Last Update：2024-04-09 02:00:43
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CAS: 19225-96-8
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CAS: 19225-96-8
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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