2-(2,4-二氯-5-氟苯甲酰基)-3-环丙胺基丙烯酸甲酯

2-(2,4-二氯-5-氟苯甲酰基)-3-环丙胺基丙烯酸甲酯 - Names and Identifiers

Name	METHYL 3-(CYCLOPROPYLAMINO)-2-(2,4-DICHLORO-5-FLUOROBENZOYL)ACRYLATE
Synonyms	methyl cyclopropyl carboxylic amine (2,4-dichloro-5-fluorobenzoyl)acrylate 2-(2,4-DICHLORO-5-FLUOROBENZOYL)-3-CYCLO METHYL 3-(CYCLOPROPYLAMINO)-2-(2,4-DICHLORO-5-FLUOROBENZOYL)ACRYLATE METHYL 2-(2,4-DICHLORO-5-FLUOROBENZOYL)-3-N,N-CYCLOPROPYLAMINOACRYLATE 2-(2,4-Dichloro-5-Fluorobenzoyl)-3-Cyclopropylamine Acrylic Methylester 2-(2,4-DICHLORO-5-FLUORO BENZOYL)-3-CYCLOPROPYLAMINO-ACRYLIC-METHYL ESTER 2-(2,4-DICHLORO-5-FLUOROBENZOYL)-3-CYCLOPROPYLAMINOACRYLIC ACID, METHYL ESTER methyl (Z)-3-(cyclopropylamino)-2-(2,4-dichloro-5-fluoro-benzoyl)prop-2-enoate 2-(2.4-Dichloro-5-fluorobenzoyl)-3-cyclopropylaminoacrylic-methylester-7-chloro- methyl (2E)-3-(cyclopropylamino)-2-[(2,4-dichloro-5-fluorophenyl)carbonyl]prop-2-enoate Benzenepropanoic acid,2,4-dichloro-a-[(cyclopropylamino)methylene]-5-fluoro-b-oxo-, methyl ester 2-(2,4-dichloro-5-fluorobenzoyl)-3-cyclopropylaminoacrylic acid, methyl ester,mixture of isomers 2-(2,4-Dichloro-5-fluorobenzoyl)-3-cyclopropylaMinoacrylic acid, Methyl ester, Mixture of isoMers Benzenepropanoic acid, 2,4-dichloro-α-[(cyclopropylamino)methylene]-5-fluoro-β-oxo-, methyl ester
CAS	105392-26-5
InChI	InChI=1/C14H12Cl2FNO3/c1-21-14(20)9(6-18-7-2-3-7)13(19)8-4-12(17)11(16)5-10(8)15/h4-7,18H,2-3H2,1H3/b9-6-

2-(2,4-二氯-5-氟苯甲酰基)-3-环丙胺基丙烯酸甲酯 - Physico-chemical Properties

Molecular Formula	C14H12Cl2FNO3
Molar Mass	332.15
Density	1.43±0.1 g/cm3(Predicted)
Melting Point	150-154°C(lit.)
Boling Point	468.4±45.0 °C(Predicted)
Flash Point	237.1°C
Vapor Presure	6.02E-09mmHg at 25°C
pKa	2.56±0.70(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.579
MDL	MFCD02683487
Physical and Chemical Properties	WGK Germany:3
Use	Intermediates for the manufacture of ciprofloxacin

2-(2,4-二氯-5-氟苯甲酰基)-3-环丙胺基丙烯酸甲酯 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
Hazard Note	Irritant

2-(2,4-二氯-5-氟苯甲酰基)-3-环丙胺基丙烯酸甲酯 - Introduction

Methyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-cyclopropylamine acrylate is an organic compound with the following properties:

1. appearance: is a colorless to yellow liquid.

2. Solubility: Soluble in common organic solvents, such as methanol, ethanol and dimethylformamide.

3. Melting point: The melting point range is about -10°C to -15°C.

4. molecular formula: C12H11Cl2FNO2.

This compound is mainly used in the field of medicine, as an organic synthesis intermediate, for the preparation of drugs and pesticides. It can be synthesized by the following steps:

1. methyl acrylate is reacted with 2,4-dichloro-5-fluorobenzoyl chloride to generate methyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-cyclopropylamine acrylate.

2. The above product can be subjected to an acid-promoted hydrolysis reaction to obtain the target compound.

It should be noted that when preparing and using 2-(2,4-dichloro-5-fluorobenzoyl)-3-cyclopropylamine methyl acrylate, the following safety precautions should be paid attention:

1. Need to operate in a well-ventilated place to avoid inhaling its vapor or gas.
2. Wear appropriate protective equipment such as gloves, goggles and protective clothing when using the compound.
3. Avoid contact with skin and eyes. If contact occurs, rinse immediately with plenty of water and seek medical assistance.
4. Store this compound in a dry, cool and airtight container, away from ignition and other flammable substances.
5. Avoid contact with strong oxidants and strong acids to prevent dangerous reactions.

Last Update：2024-04-09 21:21:28