2-Chloro-3-fluoro-5-methylpyridine
2-Chloro-3-fluoro-5-methylpyridine
CAS: 34552-15-3
Molecular Formula: C6H5ClFN
2-Chloro-3-fluoro-5-methylpyridine - Names and Identifiers
2-Chloro-3-fluoro-5-methylpyridine - Physico-chemical Properties
| Molecular Formula | C6H5ClFN |
| Molar Mass | 145.56 |
| Density | 1.264±0.06 g/cm3(Predicted) |
| Melting Point | 29-30 °C |
| Boling Point | 92°C/25mmHg(lit.) |
| Flash Point | 65.212°C |
| Vapor Presure | 1.014mmHg at 25°C |
| Appearance | Solid |
| Color | White |
| pKa | 0.35±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.504 |
| MDL | MFCD06658238 |
2-Chloro-3-fluoro-5-methylpyridine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Class | IRRITANT |
2-Chloro-3-fluoro-5-methylpyridine - Introduction
It is an organic compound with the chemical formula of C6H5ClFN. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: It is a colorless to light yellow liquid.
-Boiling point: approximately 126-127°C.
-Density: about 1.36g/cm³.
-Solubility: Soluble in many organic solvents, such as ethanol, ether and dimethylformamide.
Use:
-is widely used as an intermediate in organic synthesis and can be used to synthesize other organic compounds.
-It can also be used as a starting material for drug synthesis, pesticide synthesis and dye synthesis.
Preparation Method:
-or can be prepared by the halogenation reaction of pyridine. First, pyridine and acetic acid undergo a chlorination reaction to produce 2-chloropyridine. The 2-chloropyridine is then converted to 2-chloro-3-fluoropyridine by a fluorination reaction. Finally, 2-chloro-3-fluoropyridine was methylated using a methylation reaction.
Safety Information:
-is an irritating compound that may irritate the eyes and skin.
-During use and handling, appropriate safety measures should be taken, including wearing protective glasses and gloves.
-Avoid inhaling the vapor of the compound and ensure that it is operated in a well-ventilated environment.
-When storing and handling, keep away from fire and oxidizing agents to avoid the risk of fire and explosion.
-During use, attention should be paid to complying with relevant safety operation procedures and regulations.
Nature:
-Appearance: It is a colorless to light yellow liquid.
-Boiling point: approximately 126-127°C.
-Density: about 1.36g/cm³.
-Solubility: Soluble in many organic solvents, such as ethanol, ether and dimethylformamide.
Use:
-is widely used as an intermediate in organic synthesis and can be used to synthesize other organic compounds.
-It can also be used as a starting material for drug synthesis, pesticide synthesis and dye synthesis.
Preparation Method:
-or can be prepared by the halogenation reaction of pyridine. First, pyridine and acetic acid undergo a chlorination reaction to produce 2-chloropyridine. The 2-chloropyridine is then converted to 2-chloro-3-fluoropyridine by a fluorination reaction. Finally, 2-chloro-3-fluoropyridine was methylated using a methylation reaction.
Safety Information:
-is an irritating compound that may irritate the eyes and skin.
-During use and handling, appropriate safety measures should be taken, including wearing protective glasses and gloves.
-Avoid inhaling the vapor of the compound and ensure that it is operated in a well-ventilated environment.
-When storing and handling, keep away from fire and oxidizing agents to avoid the risk of fire and explosion.
-During use, attention should be paid to complying with relevant safety operation procedures and regulations.
Last Update：2024-04-09 21:01:54
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