6-Chloro-5-fluoro-3-picoline

6-Chloro-5-fluoro-3-picoline - Names and Identifiers

Name	2-Chloro-3-fluoro-5-methylpyridine
Synonyms	2-Chloro-3-fluoro-5-picoline 6-Chloro-5-fluoro-3-picoline 2-CHLORO-3-FLUORO-5-PICOLINE 2-CHLORO-3-FLUORO-5-METHYLPYRIDINE 2-Chloro-3-fluoro-5-methylpyridine Pyridine, 2-chloro-3-fluoro-5-methyl- 2-Chloro-3-fluoro-5-picoline 2-Chloro-3-fluoro-5-methylpyridine
CAS	34552-15-3
InChI	InChI=1/C6H5ClFN/c1-4-2-5(8)6(7)9-3-4/h2-3H,1H3

6-Chloro-5-fluoro-3-picoline - Physico-chemical Properties

Molecular Formula	C6H5ClFN
Molar Mass	145.56
Density	1.264±0.06 g/cm3(Predicted)
Melting Point	29-30 °C
Boling Point	92°C/25mmHg(lit.)
Flash Point	65.212°C
Vapor Presure	1.014mmHg at 25°C
Appearance	Solid
Color	White
pKa	0.35±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.504
MDL	MFCD06658238

6-Chloro-5-fluoro-3-picoline - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

6-Chloro-5-fluoro-3-picoline - Introduction

It is an organic compound with the chemical formula of C6H5ClFN. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: It is a colorless to light yellow liquid.
-Boiling point: approximately 126-127°C.
-Density: about 1.36g/cm³.
-Solubility: Soluble in many organic solvents, such as ethanol, ether and dimethylformamide.

Use:
-is widely used as an intermediate in organic synthesis and can be used to synthesize other organic compounds.
-It can also be used as a starting material for drug synthesis, pesticide synthesis and dye synthesis.

Preparation Method:
-or can be prepared by the halogenation reaction of pyridine. First, pyridine and acetic acid undergo a chlorination reaction to produce 2-chloropyridine. The 2-chloropyridine is then converted to 2-chloro-3-fluoropyridine by a fluorination reaction. Finally, 2-chloro-3-fluoropyridine was methylated using a methylation reaction.

Safety Information:
-is an irritating compound that may irritate the eyes and skin.
-During use and handling, appropriate safety measures should be taken, including wearing protective glasses and gloves.
-Avoid inhaling the vapor of the compound and ensure that it is operated in a well-ventilated environment.
-When storing and handling, keep away from fire and oxidizing agents to avoid the risk of fire and explosion.
-During use, attention should be paid to complying with relevant safety operation procedures and regulations.

Last Update：2024-04-09 21:01:54