2-Difluoromethyl-1H-benzoimidazole

2-Difluoromethyl-1H-benzoimidazole - Names and Identifiers

Name	2-Difluoromethyl-1H-benzoimidazole
Synonyms	2-(Difluoromethyl) 2-Difluoromethylbenzimidazole 2-(Difluormethyl)-1H-benzimidazol 2-Difluoromethyl-1H-benzoimidazole 2-(Difluoromethyl)-1H-benzimidazole 1H-benzimidazole, 2-(difluoromethyl)- 2-(difluoroMethyl)-1H-1,3-benzodiazole 1H-benzo[d]imidazole, 2-(difluoromethyl)- 1H-Benzimidazole,2-(difluoromethyl)-(9CI)
CAS	705-09-9
InChI	InChI=1/C8H6F2N2/c9-7(10)8-11-5-3-1-2-4-6(5)12-8/h1-4,7H,(H,11,12)

2-Difluoromethyl-1H-benzoimidazole - Physico-chemical Properties

Molecular Formula	C8H6F2N2
Molar Mass	168.14
Density	1.366±0.06 g/cm3(Predicted)
Melting Point	155.0 to 159.0 °C
Boling Point	57-62 °C(Press: 5 Torr)
Flash Point	141.1°C
Vapor Presure	0.00114mmHg at 25°C
Maximum wavelength(λmax)	276nm(EtOH)(lit.)
pKa	10.43±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.595
Use	This product is for scientific research only and shall not be used for other purposes.

2-Difluoromethyl-1H-benzoimidazole - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

2-Difluoromethyl-1H-benzoimidazole - Introduction

It is an organic compound with a chemical formula of C8H5F2N and a relative molecular mass of 161.13. Its nature is as follows:

1. Appearance: It is a white crystalline solid.
2. melting point: about 173-175 degrees Celsius.
3. Solubility: Soluble in organic solvents such as ethanol, dimethylformamide and chloroform, insoluble in water.

About its use:
calcium is an important intermediate compound widely used in the pharmaceutical and pesticide industries. Specific applications include:
1. Drug development: It can be used as an intermediate for the synthesis of antibacterial drugs and antiviral drugs.
2. pesticide manufacturing: used in synthetic pesticides and herbicides and other agricultural chemicals.
3. Chemical synthesis: It can be used for coupling and substitution reactions in organic synthesis.

Preparation Method:
There are many synthesis methods, one of the common synthesis methods is as follows:
By introducing a difluoromethyl group on the benzimidazole ring, a common method is to react with a proper amount of difluoromethylating reagent, such as diiodomethane or diiodomethanesulfonamide, with benzimidazole under suitable reaction conditions to obtain the target product.

Safety Information:
Because it is an organic compound, it poses a potential health and safety risk. Therefore, the following items should be paid attention to in operation and use:
1. Avoid contact with skin, eyes and respiratory tract. In case of contact, immediately flush the affected area with plenty of clean water and seek medical attention.
2. When operating indoors, please ensure adequate ventilation to avoid inhaling its vapors.
3. storage should be kept in a dry, cool, ventilated place, away from fire and flammable materials.

Since the exact safety data depends on the specific experimental conditions and use, please consult and follow the relevant safety technical information and operating instructions before use.

Last Update：2024-04-09 21:54:55