2-Iodo-5-hydroxypyridine

2-Iodo-5-hydroxypyridine - Names and Identifiers

Name	2-Iodo-5-hydroxypyridine
Synonyms	iodopyridin-3-ol 6-Iodo-3-pyridinol 6-Iodopyridin-3-ol 3-Pyridinol, 6-iodo- 5-Hydroxy-2-iodopyridine 2-Iodo-5-hydroxypyridine
CAS	129034-38-4
InChI	InChI=1/C5H4INO/c6-5-2-1-4(8)3-7-5/h1-3,8H

2-Iodo-5-hydroxypyridine - Physico-chemical Properties

Molecular Formula	C5H4INO
Molar Mass	221
Density	2.142±0.06 g/cm3(Predicted)
Melting Point	149-151 °C
Boling Point	399.7±27.0 °C(Predicted)
Flash Point	195.52°C
Solubility	Acetone (Slightly), DMSO (Slightly)
Vapor Presure	0mmHg at 25°C
Appearance	Solid
Color	Light Beige
pKa	8.79±0.10(Predicted)
Storage Condition	2-8°C(protect from light)
Refractive Index	1.683

2-Iodo-5-hydroxypyridine - Introduction

2-iodine -5-hydroxyl pyridine, chemical formula C5H3IN2O, is an organic compound. It is a white solid with a special smell. The following are some information about the properties, uses, preparation and safety of 2-iodo-5-hydroxypyridine:

Nature:
1. Appearance: white solid
2. molecular weight: 222.99g/mol
3. Melting point: 148-150°C
4. Solubility: Soluble in organic solvents such as alcohols, ethers and chlorinated hydrocarbons, insoluble in water.

Use:
1. chemical synthesis: 2-iodine -5-hydroxyl pyridine can be used as an important intermediate in organic synthesis, for the synthesis of other organic compounds.
2. Drug research: Due to its special structure, 2-iodo-5-hydroxypyridine has certain application potential in the field of drug research, such as as an antibacterial agent and a precursor of antiviral drugs.

Preparation Method:
The preparation of 2-iodo-5-hydroxypyridine is usually carried out by the following chemical reactions:
Under alkaline conditions, 2-pyridinecarboxaldehyde is reacted with iodo hydrogen acid to obtain the corresponding 2-(iodomethyl)-5-hydroxypyridine compound. The final product 2-iodo-5-hydroxypyridine is then obtained by reduction or other reactions.

Safety Information:
1. 2-Iodo-5-hydroxypyridine should be used in a laboratory or industrial environment and comply with relevant safety procedures.
2. It may be irritating to the eyes, skin and respiratory tract. Wear appropriate personal protective equipment (such as gloves, goggles and protective mask) when exposed.
3. should be stored in a sealed container, avoid contact with air, moisture and light.
4. in the treatment of 2-iodine -5-hydroxyl pyridine, should avoid direct contact with the skin and inhalation of its volatiles, maintain good ventilation conditions. In case of contact, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 15:17:51