2-氯-5-三氟甲基嘧啶
2-chloro-5-(trifluoromethyl)pyrimidine
CAS: 69034-12-4
Molecular Formula: C5H2ClF3N2
2-氯-5-三氟甲基嘧啶 - Names and Identifiers
| Name | 2-chloro-5-(trifluoromethyl)pyrimidine |
| Synonyms | 2-chloro-5-(trifluoromethyl)- (9CI) 2-Chloro-5-trifluoromethyl-pyrimidine 2-chloro-5-(trifluoromethyl)pyrimidine 2-Chloro-5-(trifluoromethyl)-1,3-diazine PyriMidine, 2-chloro-5-(trifluoroMethyl)- pyrimidine, 2-chloro-5-(trifluoromethyl)- Pyrimidine, 2-chloro-5-(trifluoromethyl)- (9CI) |
| CAS | 69034-12-4 |
| InChI | InChI=1/C5H2ClF3N2/c6-4-10-1-3(2-11-4)5(7,8)9/h1-2H |
| InChIKey | TYCYTQLXAIDJNF-UHFFFAOYSA-N |
2-氯-5-三氟甲基嘧啶 - Physico-chemical Properties
| Molecular Formula | C5H2ClF3N2 |
| Molar Mass | 182.53 |
| Density | 1.504±0.06 g/cm3(Predicted) |
| Melting Point | 48-52°C |
| Boling Point | 222.1±35.0 °C(Predicted) |
| Flash Point | 71℃ |
| Vapor Presure | 0.154mmHg at 25°C |
| pKa | -3.48±0.22(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.445 |
2-氯-5-三氟甲基嘧啶 - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 2811 |
| WGK Germany | 3 |
| Hazard Class | 6.1 |
| Packing Group | Ⅲ |
2-氯-5-三氟甲基嘧啶 - Introduction
2-choro-5-(trifluoromethyl)pyrimidine is an organic compound with the chemical formula C5H2ClF3N2. It is a white crystalline powder, soluble in many organic solvents.
2-choro-5-(trifluoromethyl)pyrimidine is widely used in organic synthesis. It is an important intermediate in many drugs, pesticides and insecticides. It can be used for the synthesis of Legionella pneumophila inhibitors, virus inhibitors, anti-tumor drugs and other compounds.
A common method for preparing 2-chloro-5-(trifluoromethyl)pyrimidine is to react 2-chloro-5-nitropyrimidine with a trifluoromethyl compound. Among them, 2-chloro-5-nitropyrimidine can be generated by the reaction of pyrimidine and thionyl chloride, and then nitrated with sodium nitrite to obtain 2-chloro-5-nitropyrimidine.
For safety information, 2-chloro-5-(trifluoromethyl)pyrimidine should be operated in a well-ventilated area, wearing protective gloves and glasses if necessary. It is irritating, and contact with skin and eyes can cause irritation and burns. Care should be taken to avoid inhalation of its dust or solution vapors during use. If inhaled or ingested by mistake, seek medical attention immediately. Contact with strong oxidants and strong acids should be avoided during storage and handling.
2-choro-5-(trifluoromethyl)pyrimidine is widely used in organic synthesis. It is an important intermediate in many drugs, pesticides and insecticides. It can be used for the synthesis of Legionella pneumophila inhibitors, virus inhibitors, anti-tumor drugs and other compounds.
A common method for preparing 2-chloro-5-(trifluoromethyl)pyrimidine is to react 2-chloro-5-nitropyrimidine with a trifluoromethyl compound. Among them, 2-chloro-5-nitropyrimidine can be generated by the reaction of pyrimidine and thionyl chloride, and then nitrated with sodium nitrite to obtain 2-chloro-5-nitropyrimidine.
For safety information, 2-chloro-5-(trifluoromethyl)pyrimidine should be operated in a well-ventilated area, wearing protective gloves and glasses if necessary. It is irritating, and contact with skin and eyes can cause irritation and burns. Care should be taken to avoid inhalation of its dust or solution vapors during use. If inhaled or ingested by mistake, seek medical attention immediately. Contact with strong oxidants and strong acids should be avoided during storage and handling.
Last Update：2024-04-09 20:02:46
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View History
2-氯-5-三氟甲基嘧啶
叔丁氧羰基-色氨酸(5-PH)
2-环丙基噻唑-5-甲醛
DAPT
2-IODOPHENYLACETIC ACID
Paxlovid impurity 14
BICYCLO[1.1.1]PENTAN-1-AMINE HYDROCHORIDE
ROBINETINIDIN CHLORIDE WITH HPLC
叔丁氧羰基-色氨酸(5-PH)
2-环丙基噻唑-5-甲醛
DAPT
2-IODOPHENYLACETIC ACID
Paxlovid impurity 14
BICYCLO[1.1.1]PENTAN-1-AMINE HYDROCHORIDE
ROBINETINIDIN CHLORIDE WITH HPLC