2066-89-9
isonicotinic acid hydrazide P-*aminosalicylate
CAS: 2066-89-9
Molecular Formula: C13H14N4O4
2066-89-9 - Names and Identifiers
| Name | isonicotinic acid hydrazide P-*aminosalicylate |
| Synonyms | Dipasic Nidrapas Fintozid PASINIAZID Pasiniazid PASINIAZIDISONIAZID AMINOSALICYLATE UV isonicotinicacidhydrazidep-*aminosalicylate isonicotinic acid hydrazide 4-aminosalicylate isonicotinic acid hydrazide P-*aminosalicylate ISONICOTINIC ACID HYDRAZIDE P-AMINOSALICYLATE SALT |
| CAS | 2066-89-9 |
| EINECS | 218-183-2 |
| InChI | InChI=1/C7H7NO3.C6H7N3O/c8-4-1-2-5(7(10)11)6(9)3-4;7-9-6(10)5-1-3-8-4-2-5/h1-3,9H,8H2,(H,10,11);1-4H,7H2,(H,9,10) |
2066-89-9 - Physico-chemical Properties
| Molecular Formula | C13H14N4O4 |
| Molar Mass | 290.27 |
| Melting Point | 142-144° |
| Boling Point | 380.8°C at 760 mmHg |
| Flash Point | 184.1°C |
| Solubility | Soluble in water |
| Vapor Presure | 1.78E-06mmHg at 25°C |
| Appearance | Solid |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| MDL | MFCD00079376 |
| Use | Used as anti-tuberculosis and leprosy drug |
2066-89-9 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
2066-89-9 - Standard
Authoritative Data Verified Data
This product is 4-pyridinecarbonyl hydrazide p-aminosalicylic acid salt. Calculated as dry product, containing C6H7N3O • C7H7N03 shall not be less than 98.0%.
Last Update：2024-01-02 23:10:35
2066-89-9 - Trait
Authoritative Data Verified Data
- This product is yellow crystalline powder, odorless.
- This product is soluble in acetone, soluble in hot water, slightly soluble in ethanol and methanol.
melting point
The melting point of this product is 139~144°C, and the melting is decomposed at the same time (General rule 0612).
Last Update：2022-01-01 13:35:15
2066-89-9 - Differential diagnosis
Authoritative Data Verified Data
- take 50mg of this product, add 5ml of water to dissolve, add 1 ml of silver nitrate test solution, the solution is white and turbid, after heating, a silver mirror is formed on the wall of the test tube.
- Take 2mg of this product, add 10ml of water to dissolve, add 2 drops of dilute hydrochloric acid and 2 drops of ferric chloride solution, that is purple.
- take this product, add water to dissolve and dilute to make a solution containing about 10% per lml, and measure by UV-Vis spectrophotometry (General 0401), there is an absorption maximum at wavelengths of 265mn and 298nm.
- The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).
Last Update：2022-01-01 13:35:15
2066-89-9 - Exam
Authoritative Data Verified Data
M-aminophenol
operation in the dark. Take an appropriate amount of this product, accurately weigh it, add the mobile phase to dissolve and quantitatively dilute it to make a solution containing about 1 mg per 1 ml, which is used as a test solution (ready to use new system); Take an appropriate amount of M-aminophenol reference, precision weighing, plus mobile phase dissolution and quantitative dilution to make a solution containing about 1.8ug per 1 ml, as a reference solution. According to high performance liquid chromatography (General rule 0512) test ^ using eighteen alkyl silane bonded silica gel as filler, phosphate buffer solution (take disodium hydrogen phosphate 3.4g and sodium dihydrogen phosphate g, add appropriate amount of water to dissolve, add 23ml of 10% tetrabutylammonium hydroxide solution, add water to ML) Methanol (90:10) as mobile phase, the detection wavelength was 280nm. In addition, appropriate amount of this product and M-aminophenol reference substance were added with mobile phase to make a mixed solution containing about 1 mg of pasniazid and 1.8ug of M-aminophenol per 1 ml, and 20ul was injected into human liquid chromatograph, the number of theoretical plates shall not be less than 5000 based on the M-aminophenol peak. The resolution of isoniazid peak, M-aminophenol peak and p-aminosalicylic acid peak shall meet the requirements. The sample solution and the reference solution were respectively injected with 20 u1 for human liquid chromatograph. If there are chromatographic peaks in the chromatogram of the test solution that are consistent with the retention time of the M-aminophenol peak, the peak area shall be calculated according to the external standard method, and shall not exceed 0.25%.
chloride
take 0.5g of this product, add water 48ml/heat and dissolve, cool, add 2ml nitric acid, shake, divide the solution into two equal parts, separate into 50ml Nessler colorimetric tube, add 1ml of silver nitrate test solution to one portion, place it for 10 minutes, filter it repeatedly with filter paper until the filtrate is completely clarified, add 7.5ml of standard sodium solution for gasification and an appropriate amount of water to make it 50ml, shake it well, as a control solution, it was placed in the dark for 5 minutes. In the other part, add 1ml of silver nitrate test solution and water to 50ml, shake well, and place in the dark for 5 minutes. If it is turbid, it should not be more concentrated (0.03%) than the control solution.
sulfate
take 2.0g of this product, add 50ml of water, heat and dissolve in water bath, cool, add 4ml of dilute hydrochloric acid, repeatedly filter until the solution is clear, the filtrate is divided into two equal parts, and place 50ml of Nessler's colorimetric tube, add 5ml of 25% barium chloride solution in one portion, shake well, place for 10 minutes, if turbid, filter repeatedly until the filtrate is clear, then add 5.0ml of standard potassium sulfate solution and appropriate amount of water to make 50ml, shake well, for 10 minutes, as a control solution. In the other portion, add 5ml of 25% barium chloride solution and an appropriate amount of water to 50ml, shake well, and place for 10 minutes. If it is turbid, compared with the control solution, it should not be more JT(0. 05).
loss on drying
take this product, with phosphorus pentoxide as desiccant, at 80°C under reduced pressure drying to constant weight, weight loss should not exceed 0.5% (General rule 0831).
Last Update：2022-01-01 13:35:16
2066-89-9 - Content determination
Authoritative Data Verified Data
take this product 0.25g, precision weighing, add glacial acetic acid 30ml to dissolve, add acetic anhydride 2ml, crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to blue as the end point, and the titration results were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 29.03mg of c6h7n3o-c7h7n03.
Last Update：2022-01-01 13:35:17
2066-89-9 - Category
Authoritative Data Verified Data
anti-tuberculosis drugs.
Last Update：2022-01-01 13:35:17
2066-89-9 - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 13:35:17
Supplier List
Multiple SpecificationsSpot supply
Product Name: Pasiniazid(Isoniazid Aminosalicylate) Visit Supplier Webpage Request for quotationCAS: 2066-89-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple SpecificationsSpot supply
Product Name: Pasiniazid(Isoniazid Aminosalicylate) Visit Supplier Webpage Request for quotationCAS: 2066-89-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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