2140-79-6
2'-O-Methyladenosine
CAS: 2140-79-6
Molecular Formula: C11H15N5O4
2140-79-6 - Names and Identifiers
| Name | 2'-O-Methyladenosine |
| Synonyms | AMI 2'-OMe-rA 2'-O-Me-Ado 2'-OMe Adenosine -O-Methyladenosine 2'-O-Methyladenosine 2'-O-Methyl-adenosine 2'-O-Methyladdenosine Adenosine, 2'-O-methyl- (2R,3R,4R,5R)-5-(6-AMino-9H-purin-9-yl)-2-(hydroxyMethyl)-4-Methoxytetrahydrofuran-3-ol |
| CAS | 2140-79-6 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C11H15N5O4/c1-19-8-7(18)5(2-17)20-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1 |
| InChIKey | FPUGCISOLXNPPC-YGHVBYMHSA-N |
2140-79-6 - Physico-chemical Properties
| Molecular Formula | C11H15N5O4 |
| Molar Mass | 281.27 |
| Density | 1.84±0.1 g/cm3(Predicted) |
| Melting Point | 200-202 C |
| Boling Point | 623.8±65.0 °C(Predicted) |
| Flash Point | 331°C |
| Water Solubility | Soluble in water. |
| Solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly) |
| Vapor Presure | 2.02E-16mmHg at 25°C |
| Appearance | White solid |
| Color | White to Off-white |
| Maximum wavelength(λmax) | ['259nm(H2O)(lit.)'] |
| pKa | 13.13±0.70(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Sensitive | Sensitive to heat |
| Refractive Index | 1.794 |
| MDL | MFCD00056002 |
2140-79-6 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29349990 |
2140-79-6 - Reference
| Reference Show more | 1. [IF=6.986] Yu-Fang Ma et al."Synthesis of a pH-Responsive Functional Covalent Organic Framework via Facile and Rapid One-Step Postsynthetic Modification and Its Application in Highly Efficient N1-Methyladenosine Extraction."Anal Chem. 2020;92(1):1424–1430 |
2140-79-6 - Reference Information
| Biological activity | 2 '-O-Methyladenosine is a residue of methylated adenine, which can be detected in the urine of normal people and adenosine deaminase (ADA). 2 '-O-Methyladenosine has unique antihypertensive activity. |
| Animal Model: | Male spontaneously hypertensive rats (SHR; 16 weeks old). |
| Dosage: | 100, 200 mg/kg. |
| Administration: | IP, single dose. |
| Result: | Exhibited a significant hypotensive effect in decreasing blood pressure by about 40-50%. |
| use | storage temperature: -20 c |
Last Update：2024-04-09 20:52:54
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