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21462-39-5

clindamycin hydrochloride

CAS: 21462-39-5

Molecular Formula: C18H34Cl2N2O5S

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21462-39-5 - Names and Identifiers

Name clindamycin hydrochloride
Synonyms Lujiemycin
CLINDAMYCIN HC
Clindamycin HCl
ClidamycinHydrochloride
clindamycin hydrochloride
CLINDAMYCINHYDROCHLORIDE,USP
CLINDAMYCINHYDROCHLORIDE,CRYSTAL
Clindaymcin Hydrochloride BP98,USP25,EP97
Clindamycin hydrochloride, Antibiotic for Culture Media Use Only
monohydrochloride,(2s-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio
methyl 7-chloro-6,7,8-trideoxy-6-({[(2R)-1-methyl-4-propylpyrrolidinium-2-yl]carbonyl}amino)-1-thio-beta-L-erythro-octopyranoside chloride
L-threo-.alpha.-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(2S,4R)-1-methyl-4-propyl-2-pyrrolidinylcarbonylamino-1-thio-, monohydrochloride
(2R,4S)-N-[2-chloro-1-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl]propyl]-1-methyl-4-propyl-pyrrolidine-2-carboxamide hydrochloride
CAS 21462-39-5
EINECS 244-398-6
InChI InChI=1/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9?,10-,11+,12?,13+,14-,15-,16-,18-;/m0./s1
InChIKey AUODDLQVRAJAJM-XJQDNNTCSA-N

21462-39-5 - Physico-chemical Properties

Molecular FormulaC18H34Cl2N2O5S
Molar Mass461.44
Melting Point141°C
Boling Point647°C at 760 mmHg
Flash Point345.1°C
Solubility H2O: 50mg/mL, clear, colorless
Vapor Presure1.79E-19mmHg at 25°C
AppearanceWhite crystalline powder
ColorWhite to Off-White
BRN4070786
Storage Condition2-8°C
StabilityHygroscopic
MDLMFCD07793327
Physical and Chemical PropertiesMelting Point: 141°C
UseLincomycin derivatives, Staphylococcus aureus, Pneumonia cocci bactericidal activity many times stronger than lincomycin

21462-39-5 - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
WGK Germany2
RTECSGF2275000
FLUKA BRAND F CODES10
HS Code29419000

21462-39-5 - Upstream Downstream Industry

Raw MaterialsLincocin Hydrochloride
Ethyl Alcohol

21462-39-5 - Reference

Reference
Show more
1. Wang Meng, Bi Qianyu, Shang Linlin, et al. Study on Bacteriostasis and Skin Irritation in Compound Clindamycin Liposome [J]. Northwest Journal of Pharmacy, 2019, 034(006):775-778.
2. Wang Meng, Shang Linlin, Lu Chuanfeng, et al. Preparation of Compound Clindamycin Liposome Gel and Study on Transdermal Release in Vitro [J]. Northwest Journal of Pharmacy, 2019, 034(004):530-533.
3. Nie Hemin, Zhang Zongyao, Huang Yumei, et al. Drug Resistance Investigation and PFGE Typing of Campylobacter Chickens in Guangdong Province [J]. Chinese Veterinary Science, 2018, 048(010):1265-1271.
4. [IF = 4.36] Qingsong Qu et al."Effects of fermented ginseng on the gut microbiota and immunity of rats with antibiotic-associated diarrhea." J Ethnopharmacol. 2021 Mar;267:113594

21462-39-5 - Standard

Authoritative Data Verified Data

This product is 7-chloro-6, 7, 8-dideoxy-6- (l-methyl-trans-4-propyl-L-2-pyrrolidinylamino) 1-thio-L-threonine-a-D-pyrrogalactopyranoside IV hydrochloride. Clindamycin (C18H33C1N205S) shall not be less than 83.0% calculated as anhydrous.

Last Update：2024-01-02 23:10:35

21462-39-5 - Trait

Authoritative Data Verified Data
  • This product is white crystalline powder; Odorless.
  • This product is easily soluble in water, soluble in methanol or pyridine, slightly soluble in ethanol, almost insoluble in acetone.

specific rotation

take this product, precision weighing, water dissolution and quantitative dilution of about 40mg per lml solution, according to the law (General 0621), specific rotation of 135 ° to 150 °.

Last Update：2022-01-01 15:04:45

21462-39-5 - Differential diagnosis

Authoritative Data Verified Data
  1. take an appropriate amount of this product and the reference substance of clindamycin, and add methanol to make a solution containing about 10 mg per 1 ml, as the test solution and the reference solution; take the appropriate amount of clindamycin control and lincomycin control, and add methanol to make a mixed solution containing 10 mg of clindamycin and 10 mg of lincomycin per 1 ml. Test according to thin layer chromatography (General rule 0502), 2ul of each of the above three Solutions was absorbed, respectively, on the same silica gel G thin layer plate, with ethyl acetate-formic acid (1.5:1) as the developer, developed, dried, and colored in iodine vapor. The mixed solution should show two clearly separated spots. The position and color of the main spot displayed by the test solution should be consistent with the position and color of the main spot of the reference solution.
  2. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
  3. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 352). If it is found that the absorption peak at 1680-1050cm-1 is inconsistent with the spectrum of the control, it is advisable to take an appropriate amount of this product, add a small amount of methanol to dissolve it, and then evaporate it on a water bath, and measure it after drying under reduced pressure.
  4. the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
  5. two items (1) and (2) above can be selected as one item.
Last Update：2022-01-01 15:04:45

21462-39-5 - Exam

Authoritative Data Verified Data

crystallinity

take this product, according to the law inspection (General 0981), should comply with the provisions.

acidity

take this product, add water to make a solution containing O.lg per lml, check according to law (General 0631) ,pH value should be 3.0~5.5.

Related substances

take an appropriate amount of this product, add the mobile phase to dissolve and dilute to make 4.0 mg of the solution was used as the test solution; An appropriate amount was taken in a precise amount and quantitatively diluted with the mobile phase to prepare a solution containing about 80ug per 1 ml as a control solution. According to the chromatographic conditions under the content determination item, 20 u1 of each of the test solution and the control solution are accurately measured and injected into the human liquid chromatograph respectively, and the chromatogram is recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the peak area of lincomycin (relative retention time is about 0.4) shall not be greater than 0.5 times (1.0%) of the main peak area of the control solution, clindamycin B (relative retention time is about 0.65) Peak area should not be greater than the control solution Main Peak area (2.0%),7-to clindamycin (relative retention time is about 0.8) the peak area shall not be greater than 0.75 times (1.5%) of the main peak area of the control solution, and the peak area of other individual impurities shall not be greater than 0.25 times (0.5%) of the main peak area of the control solution, the sum of each impurity peak area shall not be greater than 3 times (6.0%) of the main peak area of the control solution.

moisture

take this product, according to the moisture determination method (General 0832 first method 1), the water content shall not exceed 6.0%.

ignition residue

not more than 0.5% (General rule 0841).

Last Update：2022-01-01 15:04:46

21462-39-5 - Content determination

Authoritative Data Verified Data

measured by high performance liquid chromatography (General 0512).

chromatographic conditions and system suitability test

silica gel bonded with eighteen alkyl silane as filler; Potassium dihydrogen phosphate solution (6.8mg of potassium dihydrogen phosphate per 1 ml, adjusted to pH 25% with 7.5 potassium hydroxide solution)-acetonitrile (55:45) as the mobile phase; The detection wavelength is 210mn; Take an appropriate amount of clindamycin control, add the mobile phase to dissolve and dilute to make 4 per 1 ml. 0 mg of the solution, 20 U1 was injected into the liquid chromatograph, and the chromatogram was recorded; The retention time of the main peak of clindamycin was about 10 minutes. Clindamycin B Peak (relative retention time about 0.65) and 7-episodic clindamycin peak (relative retention time about 0.8) and the 7-episodic clindamycin peak should be separated from the clindamycin peak by greater than 3.0.

assay

take about 50mg of this product, weigh it accurately, put it in a 50ml measuring flask, add the mobile phase to dissolve and dilute to the scale, shake it well, and use it as a test solution, the chromatogram was recorded by injection of 20u1 into human liquid chromatograph, and an appropriate amount of clindamycin reference substance was taken for determination by the same method. The content of c18h33c1n205 S was calculated by peak area according to external standard method.

Last Update：2022-01-01 15:04:47

21462-39-5 - Category

Authoritative Data Verified Data

antibiotics.

Last Update：2022-01-01 15:04:47

21462-39-5 - Storage

Authoritative Data Verified Data

sealed storage.

Last Update：2022-01-01 15:04:47

21462-39-5 - Clindamycin hydrochloride capsules

Authoritative Data Verified Data

This product contains clindamycin hydrochloride according to clindamycin (C18H33CIN205S) calculation, should be 90.0% ~ 110.0% of the label amount.

trait

The content of this product is white powder or crystalline powder or granules.

identification

  1. take an appropriate amount of the contents of this product, add methanol to make a solution containing 10 mg of clindamycin per 1 ml, shake for 2-3 minutes, stand still, and take the supernatant as the test solution, according to clindamycin hydrochloride under identification (1) test, showed the same results.
  2. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
  3. the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
  4. two items (1) and (2) above can be selected as one item.

examination

  • the contents under the item of difference in loading amount of related substances should be mixed uniformly, and the appropriate amount (about equivalent to clindamycin lOOmg) should be accurately weighed and taken, add mobile phase to dissolve and dilute to make clindamycin in about 1 ml 4.0 mg of solution, filtration, take the filtrate, according to the method under the item of clindamycin hydrochloride determination, should comply with the provisions.
  • water the content of this product should be taken in an appropriate amount, and the water content should not exceed 0832 as determined by the moisture determination method (General rule 7.0%, first method 1).
  • others should comply with the relevant provisions under the capsule (General 0103).

Content determination

take the contents under the difference of loading amount, mix evenly, weigh an appropriate amount (about equivalent to clindamycin 0.lg) accurately, put it in a 100ml measuring flask, add the mobile phase to dissolve and dilute to the scale, shake, filter, take the filtrate as a test solution, according to the method under the item of clindamycin hydrochloride, obtained.

category

with clindamycin hydrochloride.

specification

Based on C18H33C1N205S (l)0.075g (2)0.lg(3)0.15g

storage

sealed storage.

Last Update：2022-01-01 15:04:48
21462-39-5
Supplier List
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Clindamycin Hydrochloride（Clindamycin Phosphate EP Impurity E） Visit Supplier Webpage Request for quotation
CAS: 21462-39-5
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CAS: 21462-39-5
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Shanghai Yuanye Bio-Technology Co., Ltd.
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Product Name: Clindamycin Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 21462-39-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Clindamycin Hydrochloride（Clindamycin Phosphate EP Impurity E） Visit Supplier Webpage Request for quotation
CAS: 21462-39-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: clindamycin hydrochloride Request for quotation
CAS: 21462-39-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple Specifications
Product Name: Clindamycin Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 21462-39-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
View History
21462-39-5
Raw Materials for 21462-39-5
Lincocin Hydrochloride
Ethyl Alcohol
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