261360-76-3
(R)-N-BOC-2-Bromophenylalanine
CAS: 261360-76-3
Molecular Formula: C14H18BrNO4
261360-76-3 - Names and Identifiers
| Name | (R)-N-BOC-2-Bromophenylalanine |
| Synonyms | BOC-D-2-BROMOPHE BOC-D-PHE(2-BR)-OH Boc-D-Phe(2-Br)-OH RARECHEM BK PT 0041 BOC-O-BROMO-D-PHE-OH BOC-D-2-BROMOPHENYLALANINE Boc-D-2-Bromophenylalanine Boc-2-Bromo-D-phenylalanine BOC-2-BROMO-D-PHENYLALANINE (R)-N-BOC-2-Bromophenylalanine (R)-N-BOC-2-BROMOPHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-D-(2-BROMOPHENYL)ALANINE |
| CAS | 261360-76-3 |
| InChI | InChI=1/C14H18BrNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-6-4-5-7-10(9)15/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m1/s1 |
261360-76-3 - Physico-chemical Properties
| Molecular Formula | C14H18BrNO4 |
| Molar Mass | 344.2 |
| Density | 1.5311 (rough estimate) |
| Melting Point | 138.4 °C |
| Boling Point | 471.3±40.0 °C(Predicted) |
| Flash Point | 238.8°C |
| Vapor Presure | 1.1E-09mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| pKa | 3.83±0.11(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.6500 (estimate) |
261360-76-3 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| Hazard Class | IRRITANT |
261360-76-3 - Introduction
(R)-N-BOC-2-Bromophenylalanine, chemically named (R)-N-BOC-2-Bromophenylalanine, is an amino acid derivative. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
(R)-N-BOC-2-Bromophenylalanine is a white to yellowish solid with a specific stereochemical configuration. It is an amino acid derivative containing a primary amino group (Boc protecting group) and a brominated phenylpropyl functional group. Its molecular formula is C13H16BrNO4 and its molecular weight is 315.18g/mol.
Use:
(R)-N-BOC-2-Bromophenylalanine is a common amino acid protecting group, which is widely used in organic synthesis and solid phase synthesis. It can be used in the synthesis of polypeptides and proteins as reaction intermediates or starting materials. In addition, it can also be used to study the Synthesis and structure-activity relationship of drug molecules.
Method:
(R)-N-BOC-2-Bromophenylalanine can be prepared by reacting 2-bromophenylalanine with Boc-anhydride under basic conditions. The specific steps include mixing 2-bromophenylalanine and Boc-anhydride and adding a base catalyst, reacting in an appropriate solvent for a period of time, and then purifying by acidification and crystallization to obtain the desired product.
Safety Information:
(R)-N-BOC-2-Bromophenylalanine is relatively safe to use under normal laboratory conditions. However, as with all chemical substances, appropriate laboratory practices and personal protective measures should be taken. It may cause irritation to the eyes, skin and respiratory system, so contact should be avoided. Wear suitable protective gloves, goggles and lab coats during use. In addition, care was taken to prevent contact with oxidizing agents and strong acids during storage and handling. When handling this compound, it is recommended to follow chemical safety procedures and relevant regulations.
Nature:
(R)-N-BOC-2-Bromophenylalanine is a white to yellowish solid with a specific stereochemical configuration. It is an amino acid derivative containing a primary amino group (Boc protecting group) and a brominated phenylpropyl functional group. Its molecular formula is C13H16BrNO4 and its molecular weight is 315.18g/mol.
Use:
(R)-N-BOC-2-Bromophenylalanine is a common amino acid protecting group, which is widely used in organic synthesis and solid phase synthesis. It can be used in the synthesis of polypeptides and proteins as reaction intermediates or starting materials. In addition, it can also be used to study the Synthesis and structure-activity relationship of drug molecules.
Method:
(R)-N-BOC-2-Bromophenylalanine can be prepared by reacting 2-bromophenylalanine with Boc-anhydride under basic conditions. The specific steps include mixing 2-bromophenylalanine and Boc-anhydride and adding a base catalyst, reacting in an appropriate solvent for a period of time, and then purifying by acidification and crystallization to obtain the desired product.
Safety Information:
(R)-N-BOC-2-Bromophenylalanine is relatively safe to use under normal laboratory conditions. However, as with all chemical substances, appropriate laboratory practices and personal protective measures should be taken. It may cause irritation to the eyes, skin and respiratory system, so contact should be avoided. Wear suitable protective gloves, goggles and lab coats during use. In addition, care was taken to prevent contact with oxidizing agents and strong acids during storage and handling. When handling this compound, it is recommended to follow chemical safety procedures and relevant regulations.
Last Update：2024-04-09 20:49:11
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