Boc-D-Phe(2-Br)-OH

Boc-D-Phe(2-Br)-OH - Names and Identifiers

Name	(R)-N-BOC-2-Bromophenylalanine
Synonyms	BOC-D-2-BROMOPHE BOC-D-PHE(2-BR)-OH Boc-D-Phe(2-Br)-OH RARECHEM BK PT 0041 BOC-O-BROMO-D-PHE-OH BOC-D-2-BROMOPHENYLALANINE Boc-D-2-Bromophenylalanine Boc-2-Bromo-D-phenylalanine BOC-2-BROMO-D-PHENYLALANINE (R)-N-BOC-2-Bromophenylalanine (R)-N-BOC-2-BROMOPHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-D-(2-BROMOPHENYL)ALANINE
CAS	261360-76-3
InChI	InChI=1/C14H18BrNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-6-4-5-7-10(9)15/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m1/s1

Boc-D-Phe(2-Br)-OH - Physico-chemical Properties

Molecular Formula	C14H18BrNO4
Molar Mass	344.2
Density	1.5311 (rough estimate)
Melting Point	138.4 °C
Boling Point	471.3±40.0 °C(Predicted)
Flash Point	238.8°C
Vapor Presure	1.1E-09mmHg at 25°C
Appearance	White powder
Color	White
pKa	3.83±0.11(Predicted)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.6500 (estimate)

Boc-D-Phe(2-Br)-OH - Risk and Safety

Hazard Symbols	Xi - Irritant
Safety Description	24/25 - Avoid contact with skin and eyes.
Hazard Class	IRRITANT

Boc-D-Phe(2-Br)-OH - Introduction

(R)-N-BOC-2-Bromophenylalanine, chemically named (R)-N-BOC-2-Bromophenylalanine, is an amino acid derivative. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
(R)-N-BOC-2-Bromophenylalanine is a white to yellowish solid with a specific stereochemical configuration. It is an amino acid derivative containing a primary amino group (Boc protecting group) and a brominated phenylpropyl functional group. Its molecular formula is C13H16BrNO4 and its molecular weight is 315.18g/mol.

Use:
(R)-N-BOC-2-Bromophenylalanine is a common amino acid protecting group, which is widely used in organic synthesis and solid phase synthesis. It can be used in the synthesis of polypeptides and proteins as reaction intermediates or starting materials. In addition, it can also be used to study the Synthesis and structure-activity relationship of drug molecules.

Method:
(R)-N-BOC-2-Bromophenylalanine can be prepared by reacting 2-bromophenylalanine with Boc-anhydride under basic conditions. The specific steps include mixing 2-bromophenylalanine and Boc-anhydride and adding a base catalyst, reacting in an appropriate solvent for a period of time, and then purifying by acidification and crystallization to obtain the desired product.

Safety Information:
(R)-N-BOC-2-Bromophenylalanine is relatively safe to use under normal laboratory conditions. However, as with all chemical substances, appropriate laboratory practices and personal protective measures should be taken. It may cause irritation to the eyes, skin and respiratory system, so contact should be avoided. Wear suitable protective gloves, goggles and lab coats during use. In addition, care was taken to prevent contact with oxidizing agents and strong acids during storage and handling. When handling this compound, it is recommended to follow chemical safety procedures and relevant regulations.

Last Update：2024-04-09 20:49:11