3-Amino-2-fluoropyridine
3-Amino-2-fluoropyridine
CAS: 1597-33-7
Molecular Formula: C5H5FN2
3-Amino-2-fluoropyridine - Names and Identifiers
| Name | 3-Amino-2-fluoropyridine |
| Synonyms | 3-Amino-2-Fluoropyrine 2-FLUOROPYRIDIN-3-AMINE 3-AMINO-2-FLUOROPYIDINE 3-AMINE-2-FLUOROPYRIDIN 2-Fluoro-3-aminopyridine 3-Amino-2-fluoropyridine 3-AMINO-2-FLUOROPYRIDINE calcium tetrafluoroborate 2-FLUORO-PYRIDIN-3-YLAMINE methyl 3-bromo-2-hydroxyisonicotinate |
| CAS | 1597-33-7 |
| EINECS | 145-896-5 |
| InChI | InChI=1/BF4.Ca/c2-1(3,4)5;/q-1;+2 |
3-Amino-2-fluoropyridine - Physico-chemical Properties
| Molecular Formula | C5H5FN2 |
| Molar Mass | 112.11 |
| Density | 1.212 |
| Boling Point | 102°C/18mmHg(lit.) |
| Flash Point | >110℃ |
| Maximum wavelength(λmax) | 284nm(lit.) |
| pKa | 1.18±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.563 |
| MDL | MFCD03095248 |
3-Amino-2-fluoropyridine - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
3-Amino-2-fluoropyridine - Introduction
3-Amino-2-fluoropyridine is an organic compound with the chemical formula C5H5FN2. The following is a description of its nature, use, preparation and safety information:
Nature:
3-Amino-2-fluoropyridine is a white crystalline solid with the characteristic properties of pyridine compounds. It is almost insoluble in water at normal temperature, but soluble in organic solvents such as alcohols, ethers, ketones and esters. It has medium volatility and strong pungent odor.
Use:
3-Amino-2-fluoropyridine is widely used in the fields of medicine, pesticide and chemical industry. It is an important intermediate for the development and production of many biologically active compounds, such as pharmaceuticals and pesticides. In the field of medicine, it is often used in the synthesis of antibiotics, antiviral drugs, cardiovascular and cerebrovascular drugs. In the field of pesticides, it can be used as an important component of insecticides, herbicides and weed control agents. In addition, due to its chemical stability, 3-Amino-2-fluoropyridine can also be used as a catalyst and solvent for organic synthesis reactions.
Method:
Generally, the preparation method of 3-Amino-2-fluoropyridine includes taking chloroacetic acid and 2-amino sodium fluoride as raw materials, and reacting to generate 3-Amino-2-fluoropyridine. The specific preparation method varies depending on the conditions and proportions used.
Safety Information:
3-Amino-2-fluoropyridine needs to pay attention to safety measures during use and storage. It is irritating and should avoid inhalation of gases, dusts or vapours and contact with skin, eyes and mucous membranes. Wear protective gloves, goggles and appropriate protective clothing during operation. In case of accidental inhalation or accidental contact, rinse immediately with plenty of water and seek medical help. In addition, it should be kept in a cool, dry, well-ventilated place during storage, away from fire and oxidants.
Nature:
3-Amino-2-fluoropyridine is a white crystalline solid with the characteristic properties of pyridine compounds. It is almost insoluble in water at normal temperature, but soluble in organic solvents such as alcohols, ethers, ketones and esters. It has medium volatility and strong pungent odor.
Use:
3-Amino-2-fluoropyridine is widely used in the fields of medicine, pesticide and chemical industry. It is an important intermediate for the development and production of many biologically active compounds, such as pharmaceuticals and pesticides. In the field of medicine, it is often used in the synthesis of antibiotics, antiviral drugs, cardiovascular and cerebrovascular drugs. In the field of pesticides, it can be used as an important component of insecticides, herbicides and weed control agents. In addition, due to its chemical stability, 3-Amino-2-fluoropyridine can also be used as a catalyst and solvent for organic synthesis reactions.
Method:
Generally, the preparation method of 3-Amino-2-fluoropyridine includes taking chloroacetic acid and 2-amino sodium fluoride as raw materials, and reacting to generate 3-Amino-2-fluoropyridine. The specific preparation method varies depending on the conditions and proportions used.
Safety Information:
3-Amino-2-fluoropyridine needs to pay attention to safety measures during use and storage. It is irritating and should avoid inhalation of gases, dusts or vapours and contact with skin, eyes and mucous membranes. Wear protective gloves, goggles and appropriate protective clothing during operation. In case of accidental inhalation or accidental contact, rinse immediately with plenty of water and seek medical help. In addition, it should be kept in a cool, dry, well-ventilated place during storage, away from fire and oxidants.
Last Update：2024-04-09 20:52:54
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