3-Chloro-N-(4-Hydroxyphenyl)Propionamide

3-Chloro-N-(4-Hydroxyphenyl)Propionamide - Names and Identifiers

Name	3-Chloro-N-(4-Hydroxyphenyl)Propionamide
Synonyms	3-chloro-N-(4-hydroxyphenyl)propanamide 3-CHLORO-N-(4-HYDROXYPHENYL)PROPIONAMIDE 3-Chloro-N-(4-Hydroxyphenyl)Propionamide propanamide, 3-chloro-N-(4-hydroxyphenyl)- Propanamide, 3-chloro-N-(4-hydroxyphenyl)-
CAS	19314-10-4
InChI	InChI=1/C9H10ClNO2/c10-6-5-9(13)11-7-1-3-8(12)4-2-7/h1-4,12H,5-6H2,(H,11,13)

3-Chloro-N-(4-Hydroxyphenyl)Propionamide - Physico-chemical Properties

Molecular Formula	C9H10ClNO2
Molar Mass	199.63
Density	1.341g/cm³
Boling Point	433.8°C at 760 mmHg
Flash Point	216.2°C
Vapor Presure	3.92E-08mmHg at 25°C
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.614

3-Chloro-N-(4-Hydroxyphenyl)Propionamide - Introduction

3-choro-n-(4-Hydroxyphenyl)Propionamide, with the chemical formula C9H9ClNO2, is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 3-Chloro-N-(4-Hydroxyphenyl)Propionamide is a white crystalline solid.
-Solubility: It is soluble in organic solvents such as alcohols, esters and ethers, and slightly soluble in water.
-Melting point: Its melting point range is 150-155 degrees Celsius.

Use:
-Pharmaceutical field: 3-choro-n-(4-Hydroxyphenyl)Propionamide is a Propionamide compound with certain pharmaceutical activity. It is used in the synthesis of certain drugs, such as non-steroidal anti-inflammatory drugs.
-Cosmetics field: It is also used as a raw material in cosmetics for skin moisturizing and antioxidant effects.

Method:
3-choro-n-(4-Hydroxyphenyl)Propionamide can be prepared by the following steps:
1. 4-hydroxybenzoic acid was obtained by reacting 4-hydroxybenzaldehyde with chloroacetic acid.
2.4-Hydroxybenzoic acid is reacted with chloro sulfite to obtain 4-Hydroxybenzoic acid thionyl chloride.
3. 4-hydroxybenzoic acid thionyl chloride is reacted with N,N-dimethylethylenediamine to give 3-chloro-N-(4-Hydroxyphenyl)Propionamide.

Safety Information:
- 3-Chloro-N-(4-Hydroxyphenyl)Propionamide should avoid direct contact with skin and eyes to avoid irritation or allergy. Personal protective equipment such as gloves and goggles should be used during use.
-Observe relevant safety procedures during storage and handling.
-When swallowing or inadvertent contact occurs, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 15:17:54