3-Fluoro-4-hydroxybenzonitrile

3-Fluoro-4-hydroxybenzonitrile - Names and Identifiers

Name	3-Fluoro-4-hydroxybenzonitrile
Synonyms	2-Fluoro-4-cyanophenol 4-CYANO-2-FLUOROPHENOL uoro-4-hydroxybenzonitriL 3-Fluoro-4-hydroxybenzonitrile 3-FLUORO-4-HYDROXY-BENZONITRIL 3-Fluoro-6-hydroxybenzonitrile 3-FLUORO-4-HYDROXYBENZONITRILE Benzonitrile, 3-fluoro-4-hydroxy- 3-FLUORO-4-HYDROXYBENZONITRILE (4-CYANO-2-FLUOROPHENOL)
CAS	405-04-9
InChI	InChI=1/C7H4FNO/c8-6-3-5(4-9)1-2-7(6)10/h1-3,10H

3-Fluoro-4-hydroxybenzonitrile - Physico-chemical Properties

Molecular Formula	C7H4FNO
Molar Mass	137.11
Density	1.34±0.1 g/cm3(Predicted)
Melting Point	133-135°C
Boling Point	253.9±25.0 °C(Predicted)
Flash Point	107.4°C
Vapor Presure	0.0111mmHg at 25°C
Appearance	White powder
pKa	6.58±0.18(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.558
MDL	MFCD00215834

3-Fluoro-4-hydroxybenzonitrile - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37/39 - Wear suitable gloves and eye/face protection
UN IDs	3439
Hazard Note	Irritant
Hazard Class	6.1
Packing Group	III

3-Fluoro-4-hydroxybenzonitrile - Reference Information

use

3-fluoro-4-hydroxybenzonitrile is an important organic intermediate, mainly used in the preparation of medicines and pesticides, and has a wide range of applications in the manufacturing process of dyes, engineering plastics and photosensitive materials.

preparation

traditional methods for synthesizing substituted hydroxybenzonitrile include ammonia oxidation, phase transfer catalytic synthesis or ammonification of benzoic acid. These methods have the disadvantages of long reaction route, large pollution and low yield. For example, 3-fluoro-4-hydroxybenzoic acid is prepared by one-step ammoniation reaction to 3-fluoro-4-hydroxybenzonitrile; 3-fluoro-4-hydroxybenzene is prepared by ammonia oxidation; 3-fluoro-4-hydroxybenzaldehyde is prepared by the reaction of hydroxylamine hydrochloride, and it can also be prepared by 4-hydroxybenzonitrile as the starting material and fluoro reaction [1]. The preparation reaction formula of 3-fluoro-4-hydroxybenzonitrile is as follows: Figure 1 Preparation reaction formula of 3-fluoro-4-hydroxybenzonitrile

Last Update：2024-04-09 15:16:37