3-Hydroxy-1-methylpyrrolidine
1-methyl-3-pyrrolidinol
CAS: 13220-33-2;99445-21-3
Molecular Formula: C5H11NO
3-Hydroxy-1-methylpyrrolidine - Names and Identifiers
3-Hydroxy-1-methylpyrrolidine - Physico-chemical Properties
| Molecular Formula | C5H11NO |
| Molar Mass | 101.15 |
| Density | 0.921g/mLat 25°C(lit.) |
| Boling Point | 50-52°C1mm Hg(lit.) |
| Flash Point | 159°F |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.132mmHg at 25°C |
| Appearance | Transparent liquid |
| Color | Colourless |
| pKa | 14.95±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | n20/D 1.464(lit.) |
| MDL | MFCD00003176 |
| Physical and Chemical Properties | Colorless transparent liquid. Boiling point 77 ℃(2.13kPa),50-52 ℃(0.133kPa), relative density of 0.921(20/4 ℃), refractive index of 1.4660. The flash point was 70 °c. Soluble in water, soluble in alcohol, ether and benzene. |
| Use | This product is for scientific research only and shall not be used for other purposes. |
3-Hydroxy-1-methylpyrrolidine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29339900 |
3-Hydroxy-1-methylpyrrolidine - Nature
Open Data Verified Data
colorless transparent liquid. The boiling point is 74~75 ℃(1. 6kPa),50~52 ℃(133Pa), and the relative density is 0.921. Refractive index 4640. Soluble in water, soluble in ethanol, ether, benzene. The flash point was 70 °c. Irritating.
Last Update：2024-01-02 23:10:35
3-Hydroxy-1-methylpyrrolidine - Preparation Method
Open Data Verified Data
- add butanetriol and glacial acetic acid to the reaction pot, stir and heat to about 100 ℃, add dry hydrogen chloride gas, and react at 90~110 ℃ for 30H, when a large amount of hydrogen chloride began to appear in the tail gas, the end point of the reaction was checked and the hydrogen chloride was stopped. After cooling, the material was discharged, washed with a saturated sodium carbonate solution, and subjected to distillation under reduced pressure, and 120 to 135 ° C. (12.6 to 13. 3kPa) fraction, I .e., 1, 4-chloro-2-butanol oily matter, yield 50% ~ 60%.
- cyclization an aqueous solution of 1, 4-chloro-2-butanol and methylamine was added to the cyclization pot, and heated to 120 ° C. Under closed heating, and the reaction was stirred for lOh. After cooling, solid sodium hydroxide was added, and the precipitated inorganic salt was filtered off. The oil layer was separated and subjected to vacuum distillation, and the fraction of 76-85 ° C. (2.1 kPa) was collected to be the finished product. Extraction of the aqueous layer with benzene also yields a portion of 1-methyl -3-pyrrolidinol. The yield was about 60%.
Last Update：2022-01-01 10:56:47
3-Hydroxy-1-methylpyrrolidine - Use
Open Data Verified Data
It is mainly used in the pharmaceutical industry.
Last Update：2022-01-01 10:56:46
3-Hydroxy-1-methylpyrrolidine - Safety
Open Data Verified Data
- toxic, its toxicity and protection method see n-methyl-2-pyrrolidone.
- the use of white iron drum packaging, lined with polyethylene film. Store in a closed container protected from light. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:56:46
3-Hydroxy-1-methylpyrrolidine - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| use | as a pharmaceutical intermediate. pharmaceutical intermediates |
| Production method | It is obtained by chlorination and cyclization of 1,2, 4-butanetriol. 1. Chlorination Add butanetriol and glacial acetic acid into the reaction pot, stir and heat to about 100 ℃, pass in dry hydrogen chloride gas, and react at 90-100 ℃ for 30h. When a large amount of hydrogen chloride begins to appear in the tail gas, check the end point of the reaction and stop passing hydrogen chloride. After cooling, discharge, wash with saturated sodium carbonate solution, carry out vacuum distillation, collect 120-135 ℃(12.7-13.3kPa) fraction, that is, 1, 4-dichloro-2-butanol, as oil, yield 50-60%. 2. Cyclization Add 1, 4-dichloro-2-butanol and methylamine aqueous solution into a cyclizing pot, heat to 120 ℃ in a closed manner, and stir for 10h. Cool, add solid sodium hydroxide, and filter out the precipitated inorganic salt. The oil layer is divided into reduced pressure distillation, and the 76-85 ℃(2.13kPa) fraction is collected, which is the finished product. Extraction of the water layer with benzene can also obtain a part of 1-methyl-3-pyrrolidone alcohol. The yield is about 60%. Each ton of product (content 80-90%) consumes 1,4-dichloro-2-butanol (90%) about 2330kg and monomethylamine (30%)5200kg. |
Last Update：2024-04-10 22:29:15
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3-Hydroxy-1-methylpyrrolidine
Hydrazinecarboxylic acid, 2-[2-(2,4-dichlorophenoxy)-1-oxopropyl]-, methyl ester (9CI)
Hydrazinecarboxylic acid, 2-[2-(2,4-dichlorophenoxy)-1-oxopropyl]-, methyl ester (9CI)