3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide
3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide
CAS: 6370-19-0
Molecular Formula: C16H18N2O
3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide - Names and Identifiers
| Name | 3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide |
| Synonyms | Einecs 228-877-7 3-AMINO-2',4'-DIMETHYL-P-TOLUANILIDE 3-methyl-2',4,4'-trimethylbenzanilide 3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide Benzamide, 3-amino-N-(2,4-dimethylphenyl)-4-methyl- |
| CAS | 6370-19-0 |
| EINECS | 228-877-7 |
| InChI | InChI=1/C22H29NO/c1-16-13-14-18(15-17(16)2)23-22(24)21-19-11-9-7-5-3-4-6-8-10-12-20(19)21/h5-8,13-15,19-21H,3-4,9-12H2,1-2H3,(H,23,24)/b7-5-,8-6+ |
3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide - Physico-chemical Properties
| Molecular Formula | C16H18N2O |
| Molar Mass | 254.33 |
| Density | 1.045g/cm3 |
| Boling Point | 502.7°C at 760 mmHg |
| Flash Point | 308.5°C |
| Vapor Presure | 3.1E-10mmHg at 25°C |
| Refractive Index | 1.563 |
3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide - Introduction
3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide is an organic compound with the chemical formula C17H19N3O. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: The compound is a white or off-white crystalline solid.
-Solubility: It dissolves in organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane, but hardly dissolves in water.
-Melting point: Its melting point is about 120-123 degrees Celsius.
Use:
-Drug research: 3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide is widely used in the field of drug research as an interesting ligand molecule, especially for trans conformation control in the development of new drugs.
-Venice diketone synthesis intermediate: It is also used as a synthetic intermediate for Venice diketone, which is an anti-cancer drug.
Preparation Method:
3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide can be prepared by the following method:
1.2,4-dimethylaniline reacts with acetyl chloride to give N-(2,4-dimethylphenyl) acetamide.
2. N-(2,4-dimethylphenyl) acetamide is reacted with hydrocyanic acid to give N-(2,4-dimethylphenyl) acetylcarbamic acid.
3. Reaction of N-(2,4-dimethylphenyl) acetylcarbamic acid with formyl chloride to give 3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide.
Safety Information:
There is limited information on the safety of 3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide. General laboratory practices should be followed when using or handling. It may be irritating to the eyes, skin and respiratory system. It is recommended to wear appropriate personal protective equipment such as lab gloves, goggles and protective masks during operation. If exposed to the compound, rinse immediately with plenty of water and seek medical help.
Nature:
-Appearance: The compound is a white or off-white crystalline solid.
-Solubility: It dissolves in organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane, but hardly dissolves in water.
-Melting point: Its melting point is about 120-123 degrees Celsius.
Use:
-Drug research: 3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide is widely used in the field of drug research as an interesting ligand molecule, especially for trans conformation control in the development of new drugs.
-Venice diketone synthesis intermediate: It is also used as a synthetic intermediate for Venice diketone, which is an anti-cancer drug.
Preparation Method:
3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide can be prepared by the following method:
1.2,4-dimethylaniline reacts with acetyl chloride to give N-(2,4-dimethylphenyl) acetamide.
2. N-(2,4-dimethylphenyl) acetamide is reacted with hydrocyanic acid to give N-(2,4-dimethylphenyl) acetylcarbamic acid.
3. Reaction of N-(2,4-dimethylphenyl) acetylcarbamic acid with formyl chloride to give 3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide.
Safety Information:
There is limited information on the safety of 3-amino-N-(2,4-dimethylphenyl)-4-methylbenzamide. General laboratory practices should be followed when using or handling. It may be irritating to the eyes, skin and respiratory system. It is recommended to wear appropriate personal protective equipment such as lab gloves, goggles and protective masks during operation. If exposed to the compound, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 15:17:59
