3-mercapto-L-valine

3-mercapto-L-valine - Names and Identifiers

Name	L-Beta,Beta-Dimethylcysteine
Synonyms	3-THIOL-VALINE L-Penicillamine L-PENICILLAMINE L-(+)-PENICILLAMINE TIMTEC-BB SBB000102 3-MERCAPTO-L-VALINE L-BETA-MERCAPTOVALINE 3,3-DIMETHYL-L-CYSTEINE L-Beta,Beta-Dimethylcysteine
CAS	1113-41-3
EINECS	214-203-9
InChIKey	VVNCNSJFMMFHPL-GSVOUGTGSA-N

3-mercapto-L-valine - Physico-chemical Properties

Molecular Formula	C5H11NO2S
Molar Mass	149.21
Density	1.113 (estimate)
Melting Point	206 °C (dec.)(lit.)
Boling Point	251.8±35.0 °C(Predicted)
Solubility	Aqueous Base (Sparingly), DMSO (Slightly, Heated), Water (Slightly)
Appearance	Morphological Crystalline Powder
Color	White to almost white
Merck	14,7088
BRN	1722374
pKa	2.13±0.12(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Stability	Hygroscopic
Refractive Index	63 ° (C=1, 1mol/L Na
MDL	MFCD00064303
Use	Uses L-Penicillamine is a metabolite of penicillin. L-Penicillamine is used in the treatment of Wilson holmium disease, Cystinuria, Scleroderma and arsenic poisoning.

3-mercapto-L-valine - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	2
RTECS	YV9445500
HS Code	29309090
Toxicity	LD50 i.p. in rats: 350 mg/kg (Jaffe)

3-mercapto-L-valine - Upstream Downstream Industry

Downstream Products

H-BETA,BETA-DIMETHYL-L-CYS(PMEOBZL)-OH

3-mercapto-L-valine - Uses and synthesis methods

Introduction

L-penicillamine is an intermediate of a specific drug. It is used to synthesize HIV-1 protease inhibitors. It has strong antiviral ability and has obvious preventive and therapeutic effects on AIDS. It can be seen from the structure that L-penicillamine belongs to amino acid compounds and contains an activated carbon atom.

application

L-penicillamine (CAS:1113-41-3) is a key intermediate of many drugs and has a broad market prospect, such as the synthesis of anti-AIDS protease inhibitors (JE-1520,JE-2147). At present, both drugs are in the clinical trial stage and have good antiviral efficacy. At the same time, it is also an important intermediate for the treatment of cardiovascular drug SD3321 and anticancer drug AG3340.

Preparation

D-penicillamine is used as raw material, acetyl chloride is used as acylating agent, and racemates acetyl-D and L-penicillamine are obtained by acylation, with a yield of 74.6%. Acetyl-D and L-penicillamine were hydrolyzed in hydrochloric acid to obtain racemate D and L-penicillamine with a yield of 76.2%.

Pharmaceutical intermediates

l-penicillamine is a key intermediate of many drugs and has a broad market prospect, such as the synthesis of anti-AIDS protease inhibitors (je-1520,je-2147). At present, these two drugs are in the clinical trial stage and have good antiviral efficacy. At the same time, it is also an important intermediate for the treatment of cardiovascular drug sd3321 and anticancer drug ag3340.

Last Update：2024-04-09 21:11:58