L-Beta,Beta-Dimethylcysteine
L-Beta,Beta-Dimethylcysteine
CAS: 1113-41-3
Molecular Formula: C5H11NO2S
L-Beta,Beta-Dimethylcysteine - Names and Identifiers
| Name | L-Beta,Beta-Dimethylcysteine |
| Synonyms | 3-THIOL-VALINE L-Penicillamine L-PENICILLAMINE L-(+)-PENICILLAMINE TIMTEC-BB SBB000102 3-MERCAPTO-L-VALINE L-BETA-MERCAPTOVALINE 3,3-DIMETHYL-L-CYSTEINE L-Beta,Beta-Dimethylcysteine |
| CAS | 1113-41-3 |
| EINECS | 214-203-9 |
| InChIKey | VVNCNSJFMMFHPL-GSVOUGTGSA-N |
L-Beta,Beta-Dimethylcysteine - Physico-chemical Properties
| Molecular Formula | C5H11NO2S |
| Molar Mass | 149.21 |
| Density | 1.113 (estimate) |
| Melting Point | 206 °C (dec.)(lit.) |
| Boling Point | 251.8±35.0 °C(Predicted) |
| Solubility | Aqueous Base (Sparingly), DMSO (Slightly, Heated), Water (Slightly) |
| Appearance | Morphological Crystalline Powder |
| Color | White to almost white |
| Merck | 14,7088 |
| BRN | 1722374 |
| pKa | 2.13±0.12(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Stability | Hygroscopic |
| Refractive Index | 63 ° (C=1, 1mol/L Na |
| MDL | MFCD00064303 |
| Use | Uses L-Penicillamine is a metabolite of penicillin. L-Penicillamine is used in the treatment of Wilson holmium disease, Cystinuria, Scleroderma and arsenic poisoning. |
L-Beta,Beta-Dimethylcysteine - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | YV9445500 |
| HS Code | 29309090 |
| Toxicity | LD50 i.p. in rats: 350 mg/kg (Jaffe) |
L-Beta,Beta-Dimethylcysteine - Upstream Downstream Industry
| Downstream Products | H-BETA,BETA-DIMETHYL-L-CYS(PMEOBZL)-OH |
L-Beta,Beta-Dimethylcysteine - Uses and synthesis methods
Introduction
L-penicillamine is an intermediate of a specific drug. It is used to synthesize HIV-1 protease inhibitors. It has strong antiviral ability and has obvious preventive and therapeutic effects on AIDS. It can be seen from the structure that L-penicillamine belongs to amino acid compounds and contains an activated carbon atom.
application
L-penicillamine (CAS:1113-41-3) is a key intermediate of many drugs and has a broad market prospect, such as the synthesis of anti-AIDS protease inhibitors (JE-1520,JE-2147). At present, both drugs are in the clinical trial stage and have good antiviral efficacy. At the same time, it is also an important intermediate for the treatment of cardiovascular drug SD3321 and anticancer drug AG3340.
Preparation
D-penicillamine is used as raw material, acetyl chloride is used as acylating agent, and racemates acetyl-D and L-penicillamine are obtained by acylation, with a yield of 74.6%. Acetyl-D and L-penicillamine were hydrolyzed in hydrochloric acid to obtain racemate D and L-penicillamine with a yield of 76.2%.
Pharmaceutical intermediates
l-penicillamine is a key intermediate of many drugs and has a broad market prospect, such as the synthesis of anti-AIDS protease inhibitors (je-1520,je-2147). At present, these two drugs are in the clinical trial stage and have good antiviral efficacy. At the same time, it is also an important intermediate for the treatment of cardiovascular drug sd3321 and anticancer drug ag3340.
Last Update：2024-04-09 21:11:58
Supplier List
Featured ProductsSpot supply
Product Name: L-Penicillamine Visit Supplier Webpage Request for quotationCAS: 1113-41-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: L-Penicillamine Visit Supplier Webpage Request for quotationCAS: 1113-41-3
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: L-Penicillamine Visit Supplier Webpage Request for quotationCAS: 1113-41-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: L-Pen-OH Visit Supplier Webpage Request for quotationCAS: 1113-41-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: L-Beta,Beta-Dimethylcysteine Visit Supplier Webpage Request for quotation
CAS: 1113-41-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1113-41-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: L-Penicillamine Visit Supplier Webpage Request for quotationCAS: 1113-41-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: L-Penicillamine Visit Supplier Webpage Request for quotationCAS: 1113-41-3
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: L-Penicillamine Visit Supplier Webpage Request for quotationCAS: 1113-41-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: L-Pen-OH Visit Supplier Webpage Request for quotationCAS: 1113-41-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: L-Beta,Beta-Dimethylcysteine Visit Supplier Webpage Request for quotation
CAS: 1113-41-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1113-41-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
L-Beta,Beta-Dimethylcysteine
4-Chloro-o-cresoxyacetic acid
sodium phenolate
Pyridine, 5-(chloroMethyl)-2-Methoxy-3-(trifluoroMethyl)-
BOC-(S)-3-AMINO-5-HEXYNOIC ACID
amfenac
2-Acetyl-6-methoxypyridine
2-Methyl-2-propanyl [(2S)-2-amino-2-phenylethyl]carbamate
6-Hydroxyhexan-6-olide
3-CHLORO-1,1-DIETHOXYPROPANE
4-Chloro-o-cresoxyacetic acid
sodium phenolate
Pyridine, 5-(chloroMethyl)-2-Methoxy-3-(trifluoroMethyl)-
BOC-(S)-3-AMINO-5-HEXYNOIC ACID
amfenac
2-Acetyl-6-methoxypyridine
2-Methyl-2-propanyl [(2S)-2-amino-2-phenylethyl]carbamate
6-Hydroxyhexan-6-olide
3-CHLORO-1,1-DIETHOXYPROPANE
Downstream Products for L-Beta,Beta-Dimethylcysteine