35305-74-9
Aceglutamide
CAS: 35305-74-9
Molecular Formula: C7H12N2O4
35305-74-9 - Names and Identifiers
| Name | Aceglutamide |
| Synonyms | AC-GLN-OH Ac-Gln-OH Aceglutamide Acetylglutamide N-ACETYL GLUTAMINE ACETYL-L-GLUTAMINE N-Acetyl-L-glutamine L-GLUTAMINE, N-ACETYL- ACETYL-L-GLUTAMINE, N- L-GLUTAMINE, N2-ACETYL- ALPHA-N-ACETYL-L-GLUTAMINE L-2-ACETAMIDOGLUTARAMIC ACID |
| CAS | 35305-74-9 |
| EINECS | 219-647-7 |
| InChI | InChI=1/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13)/t5-/m0/s1 |
35305-74-9 - Physico-chemical Properties
| Molecular Formula | C7H12N2O4 |
| Molar Mass | 188.18 |
| Density | 1.290±0.06 g/cm3(Predicted) |
| Melting Point | 206-208°C |
| Boling Point | 430.5±40.0 °C(Predicted) |
| Specific Rotation(α) | -12.4 º (c=2.5% in H2O) |
| Solubility | DMSO (Slightly, Heated, Sonicated), Water (Sparingly, Heated, Sonicated) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 2.19±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD00038159 |
| Physical and Chemical Properties | White crystalline substance; Odorless, tasteless; Soluble in water, ethanol and ethyl acetate; mp 197 ℃. |
35305-74-9 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
35305-74-9 - Reference
| Reference Show more | 1. Fang Yuchen, Wan Hai Tong, Yu Li, etc. Pharmacokinetics of Safflower Extract and Aceglutamide Injection active ingredient in cerebral ischemia model rats [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 043(009):1940-1945. 2. Xu, Shouchao, et al. "A Study on Acetylglutamine Pharmaceutics in Rat Blood and Brain Based on Liquid Chromatography-Tandem Mass spectroscopy and Microdialysis Technique." Frontiers in Pharmacology 11 (2020): 508. 3. [IF=6.057] Mengnan Jiang et al."Rapid electrochemical detection of domoic acid based on polydopamine/reduced graphene oxide coupled with in-situ imprinted polyacrylamide."Talanta. 2022 Jan;236:122885 |
35305-74-9 - Standard
Authoritative Data Verified Data
This product is N2-acetyl glutamine. The content of C7H12N204 shall not be less than 98.0% calculated as dried product.
Last Update：2024-01-02 23:10:35
35305-74-9 - Trait
Authoritative Data Verified Data
melting point
The melting point of this product (General 0612) is 194~198°C.
specific rotation
take this product, precision weighing, adding water to dissolve and quantitatively dilute the solution containing 20mg per lml, according to the law (General 0621), the specific rotation is -11. 5 ° to 13 °. 5 degrees.
- This product is white crystalline powder; Odorless.
- This product is soluble in water and slightly soluble in ethanol.
Last Update：2022-01-01 11:29:17
35305-74-9 - Differential diagnosis
Authoritative Data Verified Data
- take 0.lg of this product, add 5ml of dilute hydrochloric acid, heat and boil for 30 minutes, and constantly add water, cool, adjust the pH value to about 6 with sodium hydroxide solution, take 2ml, add about 2mg of ninhydrin, heat, should be blue-purple. Another 50mg of this product, add water 2ml and ninhydrin about 2mg, heating, does not show blue purple.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 539).
Last Update：2022-01-01 11:29:18
35305-74-9 - Exam
Authoritative Data Verified Data
transmittance of solution
take 0.50g of this product, add water 20ml to dissolve, according to UV-visible spectrophotometry (General rule 0401), measure the transmittance at 430nm wavelength, not less than 95.0%.
chloride
take 0.40g of this product and check it according to law (General rule 0801). Compared with the control solution made of 8.0ml of standard sodium chloride solution, it should not be more concentrated (0.02%).
sulfide
take this product 1.25g, inspection according to law (General 0803), should meet the requirements (0.0004%).
Related substances
take this product, add mobile phase to dissolve and dilute to make a solution containing about 1 mg per 1ml as a test solution; Take 1ml for precision measurement and put it in a 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the chromatographic conditions under the content determination item, 20 u1 of the test solution and the control solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (1.0% ) , the sum of each impurity peak area shall not be greater than 2 times (2.0%) of the main peak area of the control solution.
loss on drying
take this product, in 105C dry to constant weight, weight loss should not exceed 1.0% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Heavy metals
take this product l. Add 23ml of water, heat it to dissolve if necessary, cool it, add 2ml of acetate buffer (pH3.5) and an appropriate amount of water to 25ml, and check it according to law (General rule 0821, Law 1), heavy metals should not be more than 10 parts per million.
Last Update：2022-01-01 11:29:18
35305-74-9 - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; 0.05mol/L potassium dihydrogen phosphate solution (adjusted to pH 10% with 3.0 phosphoric acid solution)-methanol (95:5) as the mobile phase; The detection wavelength is 210nm to take the appropriate amount of aceglutamide control and glutamine control, and put it in the same measuring flask, and the mobile phase is dissolved and diluted to make about 0.1 mg of the solution, mixing, take 20m injection liquid chromatography. The separation degree of aceglutamide peak and glutamine peak should be more than 7.0, and the number of theoretical plates should not be less than 2000 calculated by aceglutamide peak.
- determination of precision weighing the appropriate amount of this product, plus mobile phase dissolution and quantitative dilution made per 1ml containing about 0. The solution of lmg was accurately measured and 204 was injected into human liquid chromatograph, and the chromatogram was recorded. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:29:19
35305-74-9 - Category
Authoritative Data Verified Data
psychostimulants.
Last Update：2022-01-01 11:29:19
35305-74-9 - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:29:20
35305-74-9 - Acetylglutamide Injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of aceglutamide. Aceglutamide-containing (C7H12N204) shall be between 90.0% and 110.0% of the labeled amount.
trait
This product is a clear colorless liquid.
identification
- take an appropriate amount of this product (about 0.25g of aceglutamide), add 2ml of hydrochloric acid solution (1-2), heat and boil for about 30 minutes, and constantly add water and cool, adjust the pH value to about 6 with sodium hydroxide solution, take 2ml, add about 2mg of ninhydrin, heat, the solution shows blue purple.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
The pH value should be 4.5 to 7. 0 (General 0631).
Related substances
an appropriate amount of the product is taken and diluted with the mobile phase to prepare a solution containing about 1 ml of acetyl glutamine in lm g as a test solution; The determination is carried out according to the method under the item of acetyl glutamine. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be more than 2 times (2.0%) the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 3 times (3.0%) of the main peak area of the control solution.
bacterial endotoxin
take this product, check according to law (General 1143), the amount of endotoxin per 1 mg aceglutamide should be less than 0.25EU.
sterile
This product is treated by membrane filtration method, washed with 0.1% sterile peptone aqueous solution (not less than 1101 per membrane), with Staphylococcus aureus as the positive control bacteria, and checked according to law (general rule), the requirements shall be met. Others should comply with the relevant provisions under injections (General rule 0102).
Content determination
precise amount of this product is appropriate, diluted with mobile phase to prepare a solution containing about 0.1 mg of aceglutamide per 1 ml, and determined according to the method under the content determination of aceglutamide.
category
Same as aceglutamide.
specification
(l )2ml:0.lg (2 )5ml:0.25g (3 )5ml:0. 3g (4)5ml : 0.6g (5) 10ml:0.5g (6)20ml : 0.6g
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:29:21
35305-74-9 - Reference Information
| use | used for biochemical research, medically used as a brain function improvement drug, used for liver coma, brain trauma, brain tumor, paralysis, mental retardation, memory disorders and other diseases. |
| production method | using L-glutamine and acetic anhydride as raw materials, the product is refined through acylation reaction. |
Last Update：2024-04-09 19:05:11
Supplier List
Spot supply
Product Name: Aceglutamide Request for quotationCAS: 2490-97-3/35305-74-9
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Aceglutamide Request for quotationCAS: 2490-97-3/35305-74-9
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: N-Acetyl-L-Glutamine Visit Supplier Webpage Request for quotation
CAS: 35305-74-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 35305-74-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Aceglutamide Request for quotationCAS: 2490-97-3/35305-74-9
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Aceglutamide Request for quotationCAS: 2490-97-3/35305-74-9
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: N-Acetyl-L-Glutamine Visit Supplier Webpage Request for quotation
CAS: 35305-74-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 35305-74-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History