363-24-6
Prostaglandin E2
CAS: 363-24-6;154170-57-7
Molecular Formula: C20H32O5
363-24-6 - Names and Identifiers
363-24-6 - Physico-chemical Properties
| Molecular Formula | C20H32O5 |
| Molar Mass | 352.47 |
| Density | 1.0601 (rough estimate) |
| Melting Point | 66-68 °C |
| Boling Point | 406.07°C (rough estimate) |
| Specific Rotation(α) | -85.5 º (c=1, C2H5OH) |
| Flash Point | 288.452°C |
| Water Solubility | insoluble |
| Solubility | ethanol: 1mg/mL |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | powder |
| Color | Clear yellow to amber |
| Merck | 14,7877 |
| BRN | 4709356 |
| pKa | pKa 4.77± 0.09(H2O,t=25±0.1,I=0.1(NaCl)) (Uncertain) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Refractive Index | 1.6120 (estimate) |
| Physical and Chemical Properties | Melting Point 66-68°C specific optical rotation -85.5 ° (c = 1, C2H5OH) water-soluble insoluble |
363-24-6 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R60 - May impair fertility R22 - Harmful if swallowed R61 - May cause harm to the unborn child |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| RTECS | UK8000000 |
| FLUKA BRAND F CODES | 8-10 |
| HS Code | 29375000 |
363-24-6 - Reference
| Reference Show more | 1. [IF=4.36] Shuang Li et al."Gastro-protective effect of edible plant Artemisia argyi in ethanol-induced rats via normalizing inflammatory responses and oxidative stress."J Ethnopharmacol. 2018 Mar;214:207 2. [IF=1.337] Li Lei et al."Effects of prostaglandin E combined with continuous renal replacement therapy on septic acute kidney injury."World J Clin Cases. 2020 Jul 6; 8(13): 2738–2748 |
363-24-6 - Nature
Open Data Verified Data
This product is a white to off-white solid. Melting Point: 64-66 °c. Hydrolysis is easy at pH<4 or pH>8. Specific rotation -61. (26 °c, c = l,THF). Soluble in methanol, ethanol, ethyl acetate, chloroform and other organic solvents, water-soluble. Prostaglandins are commonly found in tissues and body fluids of humans and animals, mainly in the reproductive system. The chemical structure of prostaglandin is a five carbon ring and two containing 7 and 8 carbon atoms of the carbon chain of twenty carbon compounds, the structure is complex, many isomers. According to the five-carbon ring and the five-carbon ring on the various substituents, can be divided into eight categories. According to the different number of side chain double bonds, it is divided into 3 categories, and more than 20 kinds of prostaglandins have been found, which can be synthesized artificially. PGE2 can stimulate the uterine smooth muscle, cause uterine contraction, the uterus of each period of pregnancy are excited, and more mild, the contraction of the role of pgf2. Strong 10~40 times.
Last Update：2024-01-02 23:10:35
363-24-6 - Use
Open Data Verified Data
- induced labor drug (uterine stimulant). For pregnancy induced labor, mid-pregnancy induced labor and therapeutic abortion, preoperative cervical dilatation. For pregnancy-induced hypertension syndrome (preeclampsia, hypertension), pregnancy with heart and kidney disease, as well as prolonged pregnancy, stillbirth, blister, amniotic membrane premature rupture, elderly Primipara can be applied.
- before application, add PGE2 2mg and sodium carbonate solution to 10 ml physiological saline and shake well for intravenous drip or cervical administration. Intravenous drip: add the above 2mg PGE2 diluent into 5% glucose solution 500mL, drip speed for full-term pregnancy induction of labor is generally 1ug per minute; For mid-term pregnancy induction of labor is 4 ~ 8ug per minute. Intrauterine intra-amniotic cavity injection is suitable for mid-pregnancy induced labor and therapeutic abortion, each injection of 200ug, 1 times every 2 hours, until the fetus/"L discharge. In the uterine cavity after injection of 3~4H, appropriate amount of oxytocin, to speed up the progress of labor. Vaginal tablets for oxytocin, to promote delivery, each 1 tablet, placed in the depth of the fornix. If invalid, 6~8h put the second tablet. Preparation (1) injection, 2mL/L ml/L (with 1mg of sodium carbonate and 10 ml of physiological saline);(2) vaginal tablets, 3mg/tablet.
Last Update：2022-01-01 11:14:08
363-24-6 - Safety
Open Data Verified Data
A small number of cases may have chills, Vomit, mild Diarrhea, generally within a short period of time can be relieved, or very easy to control after symptomatic treatment; Intravenous drip have similar symptoms of phlebitis, disappeared after drug withdrawal; during the medication, the uterine contraction should be closely observed and the dosage should be adjusted at any time.
To prevent uterine contractions too strong and the occurrence of uterine rupture. Storage closed cold preservation.
Last Update：2022-01-01 11:14:08
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Email: sales@crene.cn
Mobile: 13396922869
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Spot supply
Product Name: Alprostadil Impurity 7(Alprostadil EP Impurity G) Visit Supplier Webpage Request for quotationCAS: 363-24-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Prostaglandin E2 Visit Supplier Webpage Request for quotationCAS: 363-24-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Dinoprostone Request for quotation
CAS: 363-24-6
Tel: 0576-88813233
Email: sales@crene.cn
Mobile: 13396922869
QQ: 9246768Send QQ message
CAS: 363-24-6
Tel: 0576-88813233
Email: sales@crene.cn
Mobile: 13396922869
QQ: 9246768
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