36341-25-0

Name	2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
Synonyms	Y109 Y-109 YL-109 4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol 4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE 4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one
CAS	36341-25-0

Molecular Formula	C14H11NO2S
Molar Mass	257.31
Storage Condition	2-8°C
In vitro study	YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells. YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells. Cell Proliferation Assay Cell Line: MCF-7 and MDA-MB-231 cells Concentration: 0.001, 0.01, 0.1, 1, 10 μM Incubation Time: 96 hours Result: Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively).
In vivo study	YL-109 (15 mg/kg; s.c. for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo. Animal Model: BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells Dosage: 15 mg/kg Administration: S.c. every 2 days for 63 days Result: Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells.

Last Update：2024-01-02 23:10:35

biological activity	YL-109 is a new anti-tumor reagent, which can inhibit the growth and invasion of breast cancer cells in vitro and in vivo.
in vitro study	YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells. YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells. Cell Proliferation Assay Cell Line: MCF-7 and MDA-MB-231 cells Concentration: 0.001, 0.01, 0.1, 1, 10 μ m Incubation Time: 96 hours Result: Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50=85.8 nM and 4.02 μ m, respectively).
Cell Line:	MCF-7 and MDA-MB-231 cells
Concentration:	0.001, 0.01, 0.1, 1, 10 μM
Incubation Time:	96 hours
Result:	Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively). Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells.
in vivo study	YL-109 (15 mg/kg; S.c. for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo. Animal model: BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells Dosage: 15 mg/kg Administration: S.c. every 2 days for 63 days result: Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells.
Animal Model:	BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells
Dosage:	15 mg/kg
Administration:	S.c. every 2 days for 63 days