4,4-Difluoropiperidine
4,4-Difluoropiperidine
CAS: 21987-29-1
Molecular Formula: C5H9F2N
4,4-Difluoropiperidine - Names and Identifiers
| Name | 4,4-Difluoropiperidine |
| Synonyms | 4,4-DIFLUOROPIPERIDINE 4,4-Difluoropiperidine 4,4-difluoropiperidinium Piperidine, 4,4-difluoro- |
| CAS | 21987-29-1 |
| InChI | InChI=1/C5H9F2N/c6-5(7)1-3-8-4-2-5/h8H,1-4H2/p+1 |
4,4-Difluoropiperidine - Physico-chemical Properties
| Molecular Formula | C5H9F2N |
| Molar Mass | 121.13 |
| Density | 1.08±0.1 g/cm3(Predicted) |
| Boling Point | 34°C 12mm |
| Flash Point | 22.9°C |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 20mmHg at 25°C |
| Appearance | Oil |
| Color | Yellow |
| pKa | 8.20±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
4,4-Difluoropiperidine - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
4,4-Difluoropiperidine - Introduction
4,4-difluoropiperidine is an organic compound with the chemical formula C5H8F2N. It is a colorless liquid with a pungent odor. The following is a description of the nature, use, preparation and safety information of 4,4-difluoropiperidine:
Nature:
-Appearance: colorless liquid
-Molecular weight: 114.12g/mol
-Boiling point: 85-86 ° C
-Density: 1.09g/cm³
-Melting point:-38 ° C
-Flash Point: 18 ° C
Use:
4,4-difluoropiperidine is mainly used as an important intermediate in organic synthesis reactions. It can be used in the preparation of pesticides, pharmaceuticals and other organic compounds. It also has some applications in the medical field, such as playing a key role in the synthesis of antiepileptic drugs and antipsychotic drugs.
Method:
The preparation of 4,4-difluoropiperidine is usually carried out by the following steps:
1.4-amino piperidine reacts with difluoromethane to generate a derivative of 4,4-difluoropperidine.
2. The derivative is subjected to a hydrolysis reaction with an alkali catalyst to generate 4,4-difluoropiperidine.
Safety Information:
The following safety information should be noted when using 4,4-difluoropiperidine:
-4,4-difluoropiperidine is an irritating chemical that may cause irritation when in contact with skin and eyes. Personal protective equipment should be worn during operation.
- 4,4-difluoropiperidine should be kept away from fire and high temperature and stored in a cool, dry place.
-When using, please follow the correct laboratory operating procedures, and follow the safety operation instructions and safety data sheets.
Nature:
-Appearance: colorless liquid
-Molecular weight: 114.12g/mol
-Boiling point: 85-86 ° C
-Density: 1.09g/cm³
-Melting point:-38 ° C
-Flash Point: 18 ° C
Use:
4,4-difluoropiperidine is mainly used as an important intermediate in organic synthesis reactions. It can be used in the preparation of pesticides, pharmaceuticals and other organic compounds. It also has some applications in the medical field, such as playing a key role in the synthesis of antiepileptic drugs and antipsychotic drugs.
Method:
The preparation of 4,4-difluoropiperidine is usually carried out by the following steps:
1.4-amino piperidine reacts with difluoromethane to generate a derivative of 4,4-difluoropperidine.
2. The derivative is subjected to a hydrolysis reaction with an alkali catalyst to generate 4,4-difluoropiperidine.
Safety Information:
The following safety information should be noted when using 4,4-difluoropiperidine:
-4,4-difluoropiperidine is an irritating chemical that may cause irritation when in contact with skin and eyes. Personal protective equipment should be worn during operation.
- 4,4-difluoropiperidine should be kept away from fire and high temperature and stored in a cool, dry place.
-When using, please follow the correct laboratory operating procedures, and follow the safety operation instructions and safety data sheets.
Last Update：2024-04-09 19:05:47
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