4-(2-Piperidinoethoxy)aniline

4-(2-Piperidinoethoxy)aniline - Names and Identifiers

Name	4-(2-piperidinoethoxy)aniline
Synonyms	4-(2-piperidinoethoxy)aniline 4-(2-Piperidinoethoxy)aniline 4-(2-piperidin-1-ylethoxy)aniline 4-(2-(Piperidin-1-yl)ethoxy)aniline Benzenamine, 4-[2-(1-piperidinyl)ethoxy]-
CAS	38948-27-5
EINECS	254-206-2
InChI	InChI=1/C13H20N2O/c14-12-4-6-13(7-5-12)16-11-10-15-8-2-1-3-9-15/h4-7H,1-3,8-11,14H2

4-(2-Piperidinoethoxy)aniline - Physico-chemical Properties

Molecular Formula	C13H20N2O
Molar Mass	220.31
Density	1.070±0.06 g/cm3(Predicted)
Melting Point	67 °C
Boling Point	377.1±22.0 °C(Predicted)
Flash Point	181.9°C
Vapor Presure	6.92E-06mmHg at 25°C
pKa	8.81±0.10(Predicted)
Storage Condition	2-8℃
Refractive Index	1.559

4-(2-Piperidinoethoxy)aniline - Introduction

4-(2-piperidinoethoxy)aniline is an organic compound with the chemical formula C13H18N2O. The following is a detailed description of the nature, use, preparation and safety information of 4-(2-piperidinoethoxy)aniline:

Nature:
-Appearance: 4-(2-piperidinoethoxy)aniline is a white to yellowish solid.
-Solubility: It is soluble in common organic solvents.
-Melting point: The melting point of 4-(2-piperidinoethoxy)aniline is about 69-72°C.
-Density: Its density is about 1.07g/cm³.

Use:
-4-(2-piperidinoethoxy)aniline is often used in organic synthesis as an intermediate or reagent.
-It can be used to synthesize important compounds in drugs, dyes and coatings.

Preparation Method:
There are many preparation methods for 4-(2-piperidinoethoxy)aniline. The following is a possible synthesis route:
1.2-piperazine hydrochloride is obtained by reacting 2-piperazine methanol with HCl.
2. SN2 reaction of 2-piperazine hydrochloride with chloroethanol to generate N-ethylchloropiperazine.
3. N-ethylchloropiperazine reacts with aniline to generate the desired product 4-(2-piperidinoethoxy)aniline under the catalysis of alkali.

Safety Information:
- 4-(2-piperidinoethoxy)aniline is irritating to the skin and eyes. Avoid contact with skin and eyes when using it.
-protective measures should be taken during use, such as wearing gloves, goggles, etc.
-Laboratory safety practices should be observed and reasonable ventilation conditions should be ensured.

Please note that 4-(2-piperazine-4-ethoxy) aniline is a chemical and has certain risks. When using and handling, please follow the correct operation method and refer to the relevant safety data form.

Last Update：2024-04-09 15:17:57