4-(3-Fluorophenyl)oxane-4-carbonitrile

4-(3-Fluorophenyl)oxane-4-carbonitrile - Names and Identifiers

Name	4-(3-Fluorophenyl)oxane-4-carbonitrile
Synonyms	4-(3-Fluorophenyl)oxane-4-carbonitrile 4-(3-Fluoro-phenyl)-tetrahydro-pyran-4-carbonitrile 4-(3-fluorophenyl)tetrahydro-2H-pyran-4-carbonitrile 2H-Pyran-4-carbonitrile, 4-(3-fluorophenyl)tetrahydro-
CAS	1035261-79-0

4-(3-Fluorophenyl)oxane-4-carbonitrile - Physico-chemical Properties

Molecular Formula	C12H12FNO
Molar Mass	205.2281832
Storage Condition	Room Temprature

4-(3-Fluorophenyl)oxane-4-carbonitrile - Introduction

4-(3-Fluorophenyl)oxane-4-carbonitrile is an organic compound with the chemical formula C10H10FNO. The following are some information about the properties, uses, preparation and safety of the compound:

Nature:
-Appearance: White solid
-Melting point: About 70-75 degrees Celsius
-Boiling point: about 320-325 degrees Celsius
-Solubility: Soluble in organic solvents, such as ether and alcohol.

Use:
-As an intermediate in organic synthesis, it can be used to synthesize other compounds.
-There are several potential anti-cancer properties being investigated in the field of medicine.

Method:
4-(3-Fluorophenyl)oxane-4-carbonitrile can be prepared by the following synthetic route:
1. First, 3-fluorobenzoic acid is reduced to 3-fluorobenzyl alcohol by hydrogenation.
2. Next, 3-fluorobenzyl alcohol was subjected to an alkylation reaction with butylium to obtain 3-fluorobenzyl lithium.
3. The obtained 3-fluorobenzyl lithium is reacted with butyric anhydride to produce 4-(3-fluorophenyl) butyric acid.
4. Finally, 4-(3-Fluorophenyl) butyric acid was esterified or cyanidated with sodium cyanide or sodium trifluoroacetate to prepare 4-(3-Fluorophenyl)oxane-4-carbonitrile.

Safety Information:
-Appropriate laboratory safety measures, including the wearing of gloves, goggles and protective clothing, should be taken when handling the compound.
-This compound may be irritating to eyes and skin. Avoid contact with skin and eyes.
-Use in a well-ventilated area and avoid inhalation, ingestion and swallowing.
-During use or handling, the correct disposal methods of chemicals should be followed and relevant safety regulations should be observed.

Last Update：2024-04-09 21:01:54