4-(4-Fluorobenzoyl)piperidin

4-(4-Fluorobenzoyl)piperidin - Names and Identifiers

Name	4-(4-Fluorobenzoyl)-Piperidine
Synonyms	4-(4-Fluorobenzoyl)piperidin 4-(4-Fluorobenzoyl)piperidine 4-(4-FLUOROBENZOYL)PIPERIDINE 4-(4-Fluorobenzoyl)-Piperidine 4-(4-Fluoro-benzoyl)-piperidine phenyl(piperidin-4-yl)methanone 4-[(3-fluorophenyl)carbonyl]piperidine 4-(4-FLUOROBENZOYL)PIPERIDINE(WXFC1042) (3-fluorophenyl)(piperidin-4-yl)methanone Methanone, (4-fluorophenyl)-4-piperidinyl- (4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANONE
CAS	56346-57-7
InChI	InChI=1/C12H15NO/c14-12(10-4-2-1-3-5-10)11-6-8-13-9-7-11/h1-5,11,13H,6-9H2

4-(4-Fluorobenzoyl)piperidin - Physico-chemical Properties

Molecular Formula	C12H14FNO
Molar Mass	207.24
Density	1.128±0.06 g/cm3(Predicted)
Melting Point	225-227 °C
Boling Point	323.2±32.0 °C(Predicted)
Flash Point	125.3°C
Vapor Presure	0.000589mmHg at 25°C
pKa	9.69±0.10(Predicted)
Storage Condition	2-8℃
Refractive Index	1.536

4-(4-Fluorobenzoyl)piperidin - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany	3

4-(4-Fluorobenzoyl)piperidin - Introduction

4-(4-Fluorobenzoyl)-Piperidine is an organic compound with the chemical formula Cflis Hfno. The following is a detailed description of its nature, use, preparation and safety information:

Nature:
-Appearance: 4-(4-Fluorobenzoyl)-Piperidine is a colorless to pale yellow solid.
-Solubility: It can be dissolved in some organic solvents, such as ethanol and dichloromethane.
-Melting point: Its melting point is about 60-65°C.

Use:
-Drug intermediate: 4-(4-Fluorobenzoyl)-Piperidine can be used as a drug intermediate for the synthesis of some drugs.
-Organic synthesis: It can be used as an important raw material and reagent in organic synthesis.

Preparation Method:
In general, the synthesis of 4-(4-Fluorobenzoyl)-Piperidine can be carried out by the following steps:
1. First, 4-fluorobenzoyl chloride and benzoyl chloride are reacted with piperidine to generate the corresponding amide compound.
2. Next, the amide group was removed by a heating reaction to obtain 4-(4-Fluorobenzoyl)-Piperidine.

Safety Information:
When handling and using 4-(4-Fluorobenzoyl)-Piperidine, you need to pay attention to the following safety precautions:
-Protective measures: Wear appropriate personal protective equipment, such as lab gloves, goggles and protective clothing.
-Ventilation conditions: Maintain good ventilation conditions during operation to prevent the accumulation of harmful gases.
-Toxicity: 4-(4-Fluorobenzoyl)-Piperidine has certain toxicity to human body, and may cause irritant reaction after exposure. Use caution and avoid direct contact with skin and eyes.
-Storage: The compound should be stored in a sealed container and kept in a cool, dry place, away from fire and incompatible substances.

Please note that the above information is for informational purposes only and that the specific use of this compound is subject to laboratory and chemical safety practices.

Last Update：2024-04-09 21:01:54