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4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene

6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE

CAS: 72873-74-6

Molecular Formula: C16H12FN3S

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4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene - Names and Identifiers

Name 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE
Synonyms SKF-86002
SKF 86002 DIHYDROCHLORIDE
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDYL)IMIDAZO[2,1-B]THIAZOLE
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PRIDYL)IMIDAZO-[2,1,B]-THAIZOLE
6-(4-FLUOROPHENYL)-5-(4-PYRIDYL)-2,3-DIHYDROIMIDAZO[2,1-B]-THIAZOLE
6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole
4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE
CAS 72873-74-6
InChIKey YOELZIQOLWZLQC-UHFFFAOYSA-N

4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene - Physico-chemical Properties

Molecular FormulaC16H12FN3S
Molar Mass297.35
Density1.39±0.1 g/cm3(Predicted)
Melting Point189-190°C(lit.)
Boling Point476.1±55.0 °C(Predicted)
Solubility DMSO: 9mg/mL, soluble
Appearancesolid
Coloroff-white
pKa4.36±0.10(Predicted)
Storage ConditionKeep in dark place,Sealed in dry,2-8°C
In vitro study SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV). SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells. SKF-86002 (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels. Western Blot Analysis Cell Line: U937 cells Concentration: 10 μM Incubation Time: 72 hours Result: Significantly reduced CD23 levels on IL-4-treated U937 cells.
In vivo study SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity. Animal Model: Lewis rats, with adjuvant-induced arthritis (AA) Dosage: 10 mg/kg, 30 mg/kg, 90 mg/kg Administration: Oral administration, daily, for 22 days Result: Significantly decreased hindleg volumes after injection of adjuvant.

4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
WGK Germany3

4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene - Preparation solution concentration reference

 1mg5mg10mg
1 mM3.363 ml16.815 ml33.629 ml
5 mM0.673 ml3.363 ml6.726 ml
10 mM0.336 ml1.681 ml3.363 ml
5 mM0.067 ml0.336 ml0.673 ml
Last Update：2024-01-02 23:10:35
4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE Visit Supplier Webpage Request for quotation
CAS: 72873-74-6
Tel: 18301782025
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE Visit Supplier Webpage Request for quotation
CAS: 72873-74-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene
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