SKF-86002

Name	6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE
Synonyms	SKF-86002 SKF 86002 DIHYDROCHLORIDE 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDYL)IMIDAZO[2,1-B]THIAZOLE 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PRIDYL)IMIDAZO-[2,1,B]-THAIZOLE 6-(4-FLUOROPHENYL)-5-(4-PYRIDYL)-2,3-DIHYDROIMIDAZO[2,1-B]-THIAZOLE 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole 4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE
CAS	72873-74-6
InChIKey	YOELZIQOLWZLQC-UHFFFAOYSA-N

Molecular Formula	C16H12FN3S
Molar Mass	297.35
Density	1.39±0.1 g/cm3(Predicted)
Melting Point	189-190°C(lit.)
Boling Point	476.1±55.0 °C(Predicted)
Solubility	DMSO: 9mg/mL, soluble
Appearance	solid
Color	off-white
pKa	4.36±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,2-8°C
In vitro study	SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV). SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells. SKF-86002 (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels. Western Blot Analysis Cell Line: U937 cells Concentration: 10 μM Incubation Time: 72 hours Result: Significantly reduced CD23 levels on IL-4-treated U937 cells.
In vivo study	SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity. Animal Model: Lewis rats, with adjuvant-induced arthritis (AA) Dosage: 10 mg/kg, 30 mg/kg, 90 mg/kg Administration: Oral administration, daily, for 22 days Result: Significantly decreased hindleg volumes after injection of adjuvant.

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3