4-AMINO-2-HYDROXY-5-HYDROXYMETHYLPYRIMIDINE
5-hydroxymethylcytosine
CAS: 1123-95-1
Molecular Formula: C5H7N3O2
4-AMINO-2-HYDROXY-5-HYDROXYMETHYLPYRIMIDINE - Names and Identifiers
4-AMINO-2-HYDROXY-5-HYDROXYMETHYLPYRIMIDINE - Physico-chemical Properties
| Molecular Formula | C5H7N3O2 |
| Molar Mass | 141.13 |
| Density | 1.3818 (rough estimate) |
| Melting Point | >299.85°C |
| Boling Point | 258.15°C (rough estimate) |
| Solubility | DMSO (Sparingly), Methanol (Slightly, Heated, Sonicated) |
| Appearance | Solid |
| Color | Pale Yellow to Beige |
| pKa | 8.61±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.6190 (estimate) |
4-AMINO-2-HYDROXY-5-HYDROXYMETHYLPYRIMIDINE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29335990 |
| Hazard Note | Irritant |
4-AMINO-2-HYDROXY-5-HYDROXYMETHYLPYRIMIDINE - Introduction
2-Hydroxy-4-amino-5-hydroxymethylpyrimidine, also known as 5,6-dihydrouracil -5-methanol, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
2-Hydroxy-4-amino-5-hydroxymethylpyrimidine is a white crystalline solid that is soluble in water. It is an important component in the structure of nucleic acid bases and is involved in the synthesis of DNA and RNA in organisms.
Use:
2-Hydroxy-4-amino-5-hydroxymethylpyrimidine is an important component of nucleic acids and nucleotides, and is widely used in the fields of biochemistry, pharmacy and medicine. It can be used as a building block for active ingredients in drugs such as antiviral drugs, anticancer drugs and antibacterial drugs. In addition, it can also be used in DNA/RNA sequencing, medical diagnosis and genetic engineering.
Preparation Method:
There are many ways to prepare 2-hydroxy-4-amino-5-hydroxymethylpyrimidine. A common method is the reaction of 3,4-dioxopyrimidine and formaldehyde under basic conditions to form 2-hydroxy-4-amino-5-hydroxymethylpyrimidine.
Safety Information:
2-Hydroxy-4-amino-5-hydroxymethylpyrimidine has low toxicity under normal use conditions. However, as an organic compound, it needs to be used and stored correctly, avoiding contact with skin and eyes. Inhalation of its dust or solution should be avoided. During handling and handling, relevant safe operating procedures should be observed, such as wearing appropriate personal protective equipment. In the event of an accident, seek medical attention immediately. Detailed safety information can be obtained in the safety data sheet of the relevant chemical.
Please note that the use of this compound and related work requires compliance with laboratory and safety practices and legal and regulatory requirements.
Nature:
2-Hydroxy-4-amino-5-hydroxymethylpyrimidine is a white crystalline solid that is soluble in water. It is an important component in the structure of nucleic acid bases and is involved in the synthesis of DNA and RNA in organisms.
Use:
2-Hydroxy-4-amino-5-hydroxymethylpyrimidine is an important component of nucleic acids and nucleotides, and is widely used in the fields of biochemistry, pharmacy and medicine. It can be used as a building block for active ingredients in drugs such as antiviral drugs, anticancer drugs and antibacterial drugs. In addition, it can also be used in DNA/RNA sequencing, medical diagnosis and genetic engineering.
Preparation Method:
There are many ways to prepare 2-hydroxy-4-amino-5-hydroxymethylpyrimidine. A common method is the reaction of 3,4-dioxopyrimidine and formaldehyde under basic conditions to form 2-hydroxy-4-amino-5-hydroxymethylpyrimidine.
Safety Information:
2-Hydroxy-4-amino-5-hydroxymethylpyrimidine has low toxicity under normal use conditions. However, as an organic compound, it needs to be used and stored correctly, avoiding contact with skin and eyes. Inhalation of its dust or solution should be avoided. During handling and handling, relevant safe operating procedures should be observed, such as wearing appropriate personal protective equipment. In the event of an accident, seek medical attention immediately. Detailed safety information can be obtained in the safety data sheet of the relevant chemical.
Please note that the use of this compound and related work requires compliance with laboratory and safety practices and legal and regulatory requirements.
Last Update：2024-04-09 20:52:54
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View History
4-AMINO-2-HYDROXY-5-HYDROXYMETHYLPYRIMIDINE
高氯酸锂 溶液
6-Bromo-3-methoxy-pyrazine-2-carboxylic acid methyl ester
5-METHYLPYRIDINE-2-BORONIC ACID
1044769-16-5
DODECANEBIOC DIHYDRAZIDE
tetramethylazanium,nitrate
2-(2-氯苯基)甘氨酸
1-乙酰基-4-哌啶甲胺盐酸盐
2-氨基-5-氯-3-碘代苄腈
高氯酸锂 溶液
6-Bromo-3-methoxy-pyrazine-2-carboxylic acid methyl ester
5-METHYLPYRIDINE-2-BORONIC ACID
1044769-16-5
DODECANEBIOC DIHYDRAZIDE
tetramethylazanium,nitrate
2-(2-氯苯基)甘氨酸
1-乙酰基-4-哌啶甲胺盐酸盐
2-氨基-5-氯-3-碘代苄腈