4-Hydroxy-6-(trifluoromethyl)pyrimidine

4-Hydroxy-6-(trifluoromethyl)pyrimidine - Names and Identifiers

Name	6-(trifluoromethyl)-4-pyrimidinol
Synonyms	6-TRIFLUOROMETHYL-4-PYRIMIDINOL 6-Trifluoromethyl-4-pyrimidinol 6-(trifluoromethyl)-4-pyrimidinol 6-(TRIFLUOROMETHYL)PYRIMIDIN-4-OL 4-PYRIMIDINOL, 6-(TRIFLUOROMETHYL)- 6-Trifluoromethyl-4(1H)-pyrimidinone 4-HYDROXY-6-TRIFLUOROMETHYLPYRIMIDINE 4-Hydroxy-6-(trifluormethyl)-pyrimidin 6-(trifluoromethyl)pyrimidin-4(1H)-one 4-Hydroxy-6-(trifluoromethyl)pyrimidine
CAS	1546-78-7
InChI	InChI=1/C5H3F3N2O/c6-5(7,8)3-1-4(11)10-2-9-3/h1-2H,(H,9,10,11)

4-Hydroxy-6-(trifluoromethyl)pyrimidine - Physico-chemical Properties

Molecular Formula	C5H3F3N2O
Molar Mass	164.09
Density	1.55±0.1 g/cm3(Predicted)
Melting Point	169-171°C(lit.)
Boling Point	130.3±50.0 °C(Predicted)
Flash Point	32.6°C
Water Solubility	Solubility in methanol (almost transparency). Slightly soluble in water.
Vapor Presure	9.76mmHg at 25°C
Appearance	White powder
Color	White
BRN	145548
pKa	6.41±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.484
MDL	MFCD00192530

4-Hydroxy-6-(trifluoromethyl)pyrimidine - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
HS Code	29335990
Hazard Class	IRRITANT

4-Hydroxy-6-(trifluoromethyl)pyrimidine - Introduction

6-(trifluoromethyl)-4-pyrimidinol, also known as TFP-OH, is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: The TFP-OH is white crystal or crystalline powder.
-Solubility: It is soluble in polar organic solvents, such as alcohols, ethers and ketones.
-Stability: It can exist stably under certain conditions, but it is more sensitive to light and heat.

Use:
- TFP-OH can be used as an important reagent in organic synthesis, especially in the synthesis of ribonucleic acid (RNA).
-It can be used to change the chemical properties of nucleotides or other organic molecules, such as introducing protecting groups or functional groups.

Method:
-The preparation method of TFP-OH is relatively simple, and is generally generated by reacting a trifluoromethyl compound with a compound containing a hydroxyl group.

Safety Information:
- TFP-OH dust can cause irritation to the respiratory tract and eyes, so it is necessary to wear appropriate personal protective equipment when handling.
-It may have a certain toxic impact on the environment, so when using and disposing, you need to follow the corresponding safety procedures.
-For TFP-OH specific safety information and risk assessments, refer to their relevant safety data forms or consult a professional.

Last Update：2024-04-09 20:49:11