4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
Isopropylantipyrine
CAS: 479-92-5
Molecular Formula: C14H18N2O
4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one - Names and Identifiers
4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one - Physico-chemical Properties
| Molecular Formula | C14H18N2O |
| Molar Mass | 230.31 |
| Density | 1.0371 (rough estimate) |
| Melting Point | 102-105°C |
| Boling Point | 372.3°C (rough estimate) |
| Flash Point | 123.8°C |
| Water Solubility | 743.6g/L(25.35 ºC) |
| Solubility | Slightly soluble in water, easily soluble in ethanol (96%) and dichloromethane. |
| Vapor Presure | 0.000347mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Merck | 14,7871 |
| BRN | 204533 |
| pKa | 1.46±0.65(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.5500 (estimate) |
| MDL | MFCD00053368 |
4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| RTECS | CD2800000 |
4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| brief introduction | isopropyl antipyrine, also known as propfenazone and benzpropyl pyrazolone, is a derivative of antipyrine, white or yellowish crystalline powder, slightly soluble in water, soluble in ether, soluble in ethanol and dichloromethane. Pyrazolone antipyretic analgesics have similar pharmacological effects with antipyrine and aminopyrine, but have little toxicity. It is clinically used for antipyretic and analgesic, with remarkable curative effect. |
| pharmacological effects | isopropyl antipyrine mechanism of action is central, antipyretic effect is roughly the same as antipyrine and aminopyrine, analgesic and anti-inflammatory effects It is slightly lower, its effect can be enhanced when combined with barbital, the action time is prolonged, and the toxicity is also increased, and it has a relaxing effect on intestinal smooth muscle. Its effect is weaker than that of poppy, and it is 4 times that of aminopyrine. This product is rarely used alone, and it is mostly combined with other antipyretic, analgesic, and anti-inflammatory drugs to enhance the therapeutic effect. It also has a synergistic effect with ephedrine and caffeine. |
| application | isopropyl antipyrine is similar to antipyrine and has antipyretic and analgesic effects. Clinically used for fever, headache, neuralgia, toothache, dysmenorrhea, etc. |
| adverse reactions | adverse reactions of isopropyl antipyrine include rash, indigestion, collapse, etc. Patients with porphyria should use it with caution. |
| biological activity | Propyphenazone (Isopropyrine) is an analgesic and antipyretic reagent, a selective cyclooxygenase-2 inhibitor, with anti-inflammatory activity. |
Last Update：2024-04-09 02:00:08
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View History
4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
Ethan-2,2,2-d3-amine (9CI)
3-(1,1-DIOXO-2,3-DIHYDRO-1H-1LAMBDA6-THIOPHEN-3-YLAMINO)-PROPIONIC ACID
METOPROLOL-D7 HYDROCHLORIDE (ISOPROPYL-D7)
乙基2-环己酮甲酸酯
(2-BENZOTHIAZOYLTHIO) SUCCINIC ACID
Ethan-2,2,2-d3-amine (9CI)
3-(1,1-DIOXO-2,3-DIHYDRO-1H-1LAMBDA6-THIOPHEN-3-YLAMINO)-PROPIONIC ACID
METOPROLOL-D7 HYDROCHLORIDE (ISOPROPYL-D7)
乙基2-环己酮甲酸酯
(2-BENZOTHIAZOYLTHIO) SUCCINIC ACID