4-methoxypyridine
4-methoxypyridine
CAS: 620-08-6
Molecular Formula: C6H7NO
4-methoxypyridine - Names and Identifiers
| Name | 4-methoxypyridine |
| Synonyms | 4-methoxypridine 4-METHOXYPYRIDINE 4-methoxypyridine Pyridine, 4-methoxy- gamma-Methoxypyridine METHYL PYRIDIN-4-YL ETHER |
| CAS | 620-08-6 |
| EINECS | 210-624-7 |
| InChI | InChI=1/C6H7NO/c1-8-6-2-4-7-5-3-6/h2-5H,1H3 |
4-methoxypyridine - Physico-chemical Properties
| Molecular Formula | C6H7NO |
| Molar Mass | 109.13 |
| Density | 1.075 g/mL at 25 °C (lit.) |
| Melting Point | 4 °C |
| Boling Point | 108-111 °C/65 mmHg (lit.) |
| Flash Point | 74 °C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 2.18mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.075 |
| Color | Clear colorless to slightly yellow |
| BRN | 108211 |
| pKa | 6.58(at 25℃) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.518-1.522 |
| Physical and Chemical Properties | Colorless or light yellow clear liquid |
| Use | Used as a pharmaceutical Intermediate |
4-methoxypyridine - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29339900 |
4-methoxypyridine - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| Introduction | 4-methoxypyridine is a pyridine derivative. Pyridine and its derivatives are not only the most important components of pesticides, drugs and materials science, but also very important organic synthesis intermediates. |
| preparation | at room temperature, dissolve (50 mmo1)4-methoxypyridine-N-oxide in 50mL acetonitrile solution, then add 1.01g(55 mmo1) cyanuric chloride (TCT) into the reaction solution in batches, TCL tracks the reaction, after the reaction is finished, add 20mL saturated sodium carbonate solution to the reaction droplets, and stir for 30min. Dichloromethane is added for extraction, the organic phase is washed with water, saturated salt is washed with water, and the solvent is spun under reduced pressure to obtain the crude product. The crude product is purified through the column to obtain the target product. Light yellow oily liquid. |
| use | as a pharmaceutical intermediate |
Last Update：2024-04-09 19:05:09
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View History
4-methoxypyridine
4-(3-CHLORO-PHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
1-胺-2-奈醇-4-磺酸
3-Methyl-1-Phenyl-5-Pyrazolone,Gpr
Methyl 2-methanesulfonylpyrimidine-5-carboxylate
Hydrazine, (1-methylethyl)-, monohydrochloride
1H-ISOINDOLE-4-CARBOXYLIC ACID, 2-[(4-FLUOROPHENYL)METHYL]-2,3-DIHYDRO-3-OXO-
190078-45-6
Febuxostat Intermediate
Sodium Bisulphite
4-(3-CHLORO-PHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
1-胺-2-奈醇-4-磺酸
3-Methyl-1-Phenyl-5-Pyrazolone,Gpr
Methyl 2-methanesulfonylpyrimidine-5-carboxylate
Hydrazine, (1-methylethyl)-, monohydrochloride
1H-ISOINDOLE-4-CARBOXYLIC ACID, 2-[(4-FLUOROPHENYL)METHYL]-2,3-DIHYDRO-3-OXO-
190078-45-6
Febuxostat Intermediate
Sodium Bisulphite