4-溴-3-硝基苯甲酸
3-nitro-4-bromobenzoic acid
CAS: 6319-40-0
Molecular Formula: C7H4BrNO4
4-溴-3-硝基苯甲酸 - Names and Identifiers
| Name | 3-nitro-4-bromobenzoic acid |
| Synonyms | RARECHEM AH CK 0042 4-bromo-3-nitrobenzoate 4-Bromo-3-nitrobenzoicaci 3-nitro-4-bromobenzoic acid 4-BROMO-3-NITROBENZOIC ACID 3-Nitro-4-bromobenzoic acid 4-Bromo-3-nitrobenzoic acid 2-Bromo-5-carboxynitrobenzene Benzoic acid, 4-bromo-3-nitro- |
| CAS | 6319-40-0 |
| InChI | InChI=1/C7H4BrNO4/c8-5-2-1-4(7(10)11)3-6(5)9(12)13/h1-3H,(H,10,11)/p-1 |
4-溴-3-硝基苯甲酸 - Physico-chemical Properties
| Molecular Formula | C7H4BrNO4 |
| Molar Mass | 246.01 |
| Density | 2.0176 (rough estimate) |
| Melting Point | 202-204°C |
| Boling Point | 340.9±32.0 °C(Predicted) |
| Flash Point | 160°C |
| Vapor Presure | 3.22E-05mmHg at 25°C |
| Appearance | White powder |
| Color | White to yellow |
| pKa | 3.35±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6200 (estimate) |
| MDL | MFCD00272137 |
4-溴-3-硝基苯甲酸 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29163990 |
| Hazard Note | Irritant |
4-溴-3-硝基苯甲酸 - Introduction
3-nitro-4-bromobenzoic acid is an organic compound with the formula C7H4BrNO4.
Nature:
-Appearance: Colorless crystal or light yellow crystalline powder.
-melting point: 215-218 ℃.
-Solubility: Solubility in water is small, soluble in ethanol, ether and chloroform and other organic solvents.
Use:
3-nitro-4-bromobenzoic acid is an important organic synthesis intermediate, which is widely used in pharmaceutical synthesis and dye industry.
-Drug synthesis: can be used as a precursor for the synthesis of some non-steroidal anti-inflammatory drugs and other drugs.
-Dye industry: can be used for synthetic dyes and pigments.
Preparation Method:
3-nitro-4-bromobenzoic acid can be prepared by nitration of 4-bromobenzoic acid. The specific steps are as follows:
1. Dissolve 4-bromobenzoic acid in a mixed solution of nitric acid and glacial acetic acid.
2. Stir the reaction mixture at low temperature.
3. The product precipitated in the reaction mixture is filtered and washed, and then dried to obtain 3-nitro-4-bromobenzoic acid.
Safety Information:
3-nitro-4-bromobenzoic acid has a stimulating effect on the skin and eyes, and should be fully cleaned after contact. During use and storage, avoid inhaling its dust and wear protective equipment if necessary. In addition, 3-nitro-4-bromobenzoic acid may also cause harm to the environment, so care should be taken to comply with relevant environmental safety regulations.
Nature:
-Appearance: Colorless crystal or light yellow crystalline powder.
-melting point: 215-218 ℃.
-Solubility: Solubility in water is small, soluble in ethanol, ether and chloroform and other organic solvents.
Use:
3-nitro-4-bromobenzoic acid is an important organic synthesis intermediate, which is widely used in pharmaceutical synthesis and dye industry.
-Drug synthesis: can be used as a precursor for the synthesis of some non-steroidal anti-inflammatory drugs and other drugs.
-Dye industry: can be used for synthetic dyes and pigments.
Preparation Method:
3-nitro-4-bromobenzoic acid can be prepared by nitration of 4-bromobenzoic acid. The specific steps are as follows:
1. Dissolve 4-bromobenzoic acid in a mixed solution of nitric acid and glacial acetic acid.
2. Stir the reaction mixture at low temperature.
3. The product precipitated in the reaction mixture is filtered and washed, and then dried to obtain 3-nitro-4-bromobenzoic acid.
Safety Information:
3-nitro-4-bromobenzoic acid has a stimulating effect on the skin and eyes, and should be fully cleaned after contact. During use and storage, avoid inhaling its dust and wear protective equipment if necessary. In addition, 3-nitro-4-bromobenzoic acid may also cause harm to the environment, so care should be taken to comply with relevant environmental safety regulations.
Last Update：2024-04-09 20:52:54
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CAS: 6319-40-0
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View History
4-溴-3-硝基苯甲酸
四(乙睛)四氟硼酸钯
Cobalt(II) stearate
Dabigatran Impurity 4 (DABRC-04)
methyl 3-[(2-chloro-5-methylphenoxy)methyl]benzoate
3-(4-ACETOXY-PHENYL)-3-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID
BENZAL CHLORIDE
(R)-5-CF3-Pyox-tBu
METHYL 3-(4-HYDROXYPHENYL)PROPIONATE
1-Propyl-3-Methyl-Imidazolium Bis(Trifluoromethylsulfonyl)Imide
四(乙睛)四氟硼酸钯
Cobalt(II) stearate
Dabigatran Impurity 4 (DABRC-04)
methyl 3-[(2-chloro-5-methylphenoxy)methyl]benzoate
3-(4-ACETOXY-PHENYL)-3-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID
BENZAL CHLORIDE
(R)-5-CF3-Pyox-tBu
METHYL 3-(4-HYDROXYPHENYL)PROPIONATE
1-Propyl-3-Methyl-Imidazolium Bis(Trifluoromethylsulfonyl)Imide