406482-19-7

406482-19-7 - Names and Identifiers

Name	(2-fluoro-5-methoxyphenyl)boronic acid
Synonyms	3-Borono-4-fluoroanisole 2-Fluoro-5-methoxyphenylboronicaci 2-Fluoro-5-methoxyphenylboronic acid 2-Fluoro-5-methoxyphenyl boronic acid (2-fluoro-5-methoxyphenyl)boronic acid (2-Fluoro-5-methoxyphenyl)boronic acid B-(2-fluoro-5-Methoxyphenyl)-Boronic acid boronic acid, B-(2-fluoro-5-methoxyphenyl)- Boronic acid, B-(2-fluoro-5-Methoxyphenyl)- Boronic acid, (2-fluoro-5-methoxyphenyl)- (9CI)
CAS	406482-19-7
InChI	InChI=1/C7H8BFO3/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4,10-11H,1H3

406482-19-7 - Physico-chemical Properties

Molecular Formula	C7H8BFO3
Molar Mass	169.95
Density	1.26±0.1 g/cm3(Predicted)
Melting Point	194-196 °C (lit.)
Boling Point	333.1±52.0 °C(Predicted)
Flash Point	155.2°C
Vapor Presure	5.55E-05mmHg at 25°C
Appearance	Solid
Color	White to yellow
pKa	7.90±0.58(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.503
MDL	MFCD04974115

406482-19-7 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S28B - S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
HS Code	29319090

406482-19-7 - Introduction

(2-fluoro-5-methoxyphenyl)boronic acid is an organic compound with a chemical formula of C7H8BFO3 and a molecular weight of 169.95g/mol. Its nature is as follows:

1. appearance: white solid powder.
2. Melting point: about 160-163°C.
3. Solubility: Soluble in common organic solvents, such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), acetonitrile (ACN), etc.

(2-fluoro-5-methoxyphenyl) The main uses of boronic acid include:

1. organic synthesis: as a substrate and reagent in organic synthesis, it is commonly used in the group conversion reaction of phenylboronic acid, such as SuZ8 reaction, Suzuki reaction, etc. It can be used as an important intermediate for the synthesis of drugs, pesticides, natural products and functional materials.

2. chemical research: can be used as a ligand of organic synthesis catalyst.

The method for preparing (2-fluoro-5-methoxyphenyl)boronic acid generally includes the following steps:

1. First, 2-fluoro-5-methoxyphenol and tri-n-butyl borane are reacted under an inert atmosphere to obtain 2-fluoro-5-methoxyphenylborane.

2. Then, 2-fluoro-5-methoxybenzoborane is reacted with dilute sulfuric acid and boric acid to obtain (2-fluoro-5-methoxyphenyl)boronic acid.

Regarding its safety information, the following precautions should be followed:

1. May be irritating to eyes, skin and respiratory system, please use personal protective equipment, such as gloves and protective glasses.
2. Avoid inhalation or contact, and operate in a well-ventilated place.
3. Avoid contact with inflammables and oxidants to prevent fire and explosion.
4. should be stored away from high temperature and fire, keep the container sealed.

to sum up,(2-fluoro-5-methoxyphenyl)boronic acid has important application value in organic synthesis, and it is necessary to pay attention to safe use during experimental operation.

Last Update：2024-04-09 21:54:55