4311-88-0
Necrostatin-1
CAS: 4311-88-0
Molecular Formula: C13H13N3OS
4311-88-0 - Names and Identifiers
| Name | Necrostatin-1 |
| Synonyms | CS-959 NECROSTATIN1 NECROSTATIN-1 Necrostatin-1 NECROSTATIN 1 MTH-DL-TRYPTOPHAN IFLAB-BB F0911-6127 5-(INDOL-3-YLMETHYL)-3-METHYL-2-THIO-HYDANTOIN |
| CAS | 4311-88-0 |
| EINECS | 200-256-5 |
4311-88-0 - Physico-chemical Properties
| Molecular Formula | C13H13N3OS |
| Molar Mass | 259.33 |
| Density | 1.40±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 151℃ |
| Boling Point | 441.9±37.0 °C(Predicted) |
| Flash Point | 93.3℃ |
| Solubility | DMSO: >10 mg/mL |
| Appearance | solid |
| Color | Pale yellow |
| pKa | 9.46±0.40(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied.? Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| Sensitive | Light Sensitive |
| MDL | MFCD00056916 |
| Physical and Chemical Properties | Bioactive Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor that inhibits TNF-α-induced cell necrosis with EC50 of 490 nM in 293T cells. Necrostatin-1 can also inhibit IDO, autophagy and apoptosis. |
| Use | Necrostatin-1 |
| In vitro study | Necrostatin-1 (1-100 μm) inhibited the overexpression and autophosphorylation of endogenous rip1. RIP1 is the primary cellular target and is responsible for Necrostatin-1 of the anti-necrotic activity. Necrostatin-1 effectively inhibits necrotic cell death triggered by many cell types. Necrostatin-1 as a small molecule inhibitor of cell necrosis, it acts on jurkat cells, inhibits RIP kinase induced cell necrosis and inhibits TNF-α induced cell necrosis, and the EC50 is 490 nM. Necrostatin-1 (1-100 μm) inhibited overexpression and autophosphorylation of endogenous rip1. RIP1 is the primary cellular target and is responsible for Necrostatin-1 of the anti-necrotic activity. Necrostatin-1 effectively inhibits necrotic cell death triggered by many cell types. Necrostatin-1 as a small molecule inhibitor of cell necrosis, it acts on jurkat cells, inhibits RIP kinase induced cell necrosis and inhibits TNF-α induced cell necrosis, and the EC50 is 490 nM. |
4311-88-0 - Risk and Safety
| Safety Description | 36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29339900 |
4311-88-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.856 ml | 19.28 ml | 38.561 ml |
| 5 mM | 0.771 ml | 3.856 ml | 7.712 ml |
| 10 mM | 0.386 ml | 1.928 ml | 3.856 ml |
| 5 mM | 0.077 ml | 0.386 ml | 0.771 ml |
Last Update：2024-01-02 23:10:35
4311-88-0 - Uses and synthesis methods
Features
Necrostatin-1 is a powerful tool to inhibit cell necrosis.
Target
Target Value
RIP1
(293T cells) 490 nM(EC50)
in vitro studies
Necrostatin-1 (1-100 μM) inhibits overexpression and endogenous RIP1 autophosphorylation. RIP1 is a primary cell target and is responsible for the anti-cell necrosis activity of Necrostatin-1. Necrostatin-1 effectively inhibit necrotizing cell death triggered by various types of cells. As a small molecule inhibitor of cell necrosis, Necrostatin-1 acts on jurkat cells to inhibit RIP kinase-induced cell necrosis and TNF-α-induced cell necrosis. EC50 is 490 nM.
Last Update：2024-04-09 21:54:55
4311-88-0 - Reference Information
| biological activity | Necrostatin-1 is a specific RIP1 inhibitor that inhibits TNF-α-induced necrosis with EC50 of 490 nM. Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor, which inhibits TNF-α-induced cell necrosis. EC50 is 490 nM in 293T cells. Necrostatin-1 can also inhibit IDO, autophagy and apoptosis. |
| in vitro study | Necrostatin-1 (1-100 μM) inhibits overexpression and endogenous RIP1 autophosphorylation. RIP1 is a primary cell target and is responsible for the anti-cell necrosis activity of Necrostatin-1. Necrostatin-1 effectively inhibit necrotizing cell death triggered by various types of cells. As a small molecule inhibitor of cell necrosis, Necrostatin-1 acts on jurkat cells to inhibit RIP kinase-induced cell necrosis and TNF-α-induced cell necrosis. EC50 is 490 nM. Necrostatin-1 (1-100 μM) inhibits overexpression and endogenous RIP1 autophosphorylation. RIP1 is a primary cell target and is responsible for the anti-cell necrosis activity of Necrostatin-1. Necrostatin-1 effectively inhibit necrotizing cell death triggered by various types of cells. As a small molecule inhibitor of cell necrosis, Necrostatin-1 acts on jurkat cells to inhibit RIP kinase-induced cell necrosis and TNF-α-induced cell necrosis. EC50 is 490 nM. |
| features | Necrostatin-1 are powerful tools for inhibiting cell necrosis. |
| target | TargetValue RIP1 (293T cells) 490 nM(EC50) |
| Target | Value |
| RIP1 (293T cells) | 490 nM(EC50) |
Last Update：2024-04-09 20:52:54
Supplier List
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Spot supply
Product Name: Necrostatin-1 Visit Supplier Webpage Request for quotationCAS: 4311-88-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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