431979-47-4
SJ-172550
CAS: 431979-47-4
Molecular Formula: C22H21ClN2O5
431979-47-4 - Names and Identifiers
431979-47-4 - Physico-chemical Properties
| Molecular Formula | C22H21ClN2O5 |
| Molar Mass | 428.87 |
| Density | 1.27±0.1 g/cm3(Predicted) |
| Boling Point | 560.8±60.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | powder |
| Color | orange |
| pKa | -0.30±0.40(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| In vitro study | The p53 pathway is disrupted in virtually every human tumor. SJ-172550 binds the p53-binding pocket of MDMX, thereby displacing p53. SJ-172550 binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. The effect of SJ-172550 is additive when combined with an MDM2 inhibitor nutlin-3a. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53. The relative stability of this complex is influenced by many factors including the reducing potential of the media, the presence of aggregates. |
431979-47-4 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
431979-47-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.332 ml | 11.659 ml | 23.317 ml |
| 5 mM | 0.466 ml | 2.332 ml | 4.663 ml |
| 10 mM | 0.233 ml | 1.166 ml | 2.332 ml |
| 5 mM | 0.047 ml | 0.233 ml | 0.466 ml |
Last Update：2024-01-02 23:10:35
431979-47-4 - Reference Information
| biological activity | SJ-172550 is a small molecule inhibitor of MDMX; the EC50 value of competitive binding to MDMX with wild-type p53 peptide is 5 μM. |
| target | IC50: 5 μM (MDMX) |
| in vitro study | The p53 pathway is disrupted in virtually every human tumor. SJ-172550 binds the p53-binding pocket of MDMX, thereby displacing p53. SJ-172550 binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. The effect of SJ-172550 is additive when combined with an MDM2 inhibitor nutlin-3a. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53. The relative stability of this complex is influenced by many factors including the reducing potential of the media, the presence of aggregates. |
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: SJ-172550 Visit Supplier Webpage Request for quotationCAS: 431979-47-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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